Varaico: Literature-Extracted Genetic Variants

Gene:MDM4
Variant:p.S342A
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MDM4

NM_002393.5:p.S342A

Associated Papers

Regulation of p53 by the 14-3-3 protein interaction network: new opportunities for drug discovery in cancer.

Falcicchio M et al.

Cell Death Discovery, 2020

Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein.

Lee JH et al.

The Journal of Biological Chemistry, 2012

Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.

LeBron C et al.

The Embo Journal, 2006

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.

Chen L et al.

The Embo Journal, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."