Associated Papers
Regulation of p53 by the 14-3-3 protein interaction network: new opportunities for drug discovery in cancer.
Falcicchio M et al.
Cell Death Discovery, 2020
AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity.
He G et al.
Molecular and Cellular Biology, 2014
Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein.
Lee JH et al.
The Journal of Biological Chemistry, 2012
Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.
Ohtsubo C et al.
Cancer Science, 2009
Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding.
Lopez-Pajares V et al.
The Journal of Biological Chemistry, 2008
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.
LeBron C et al.
The Embo Journal, 2006
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.
Chen L et al.
The Embo Journal, 2005
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