Varaico: Literature-Extracted Genetic Variants

Gene:MDM4
Variant:p.T454M
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MDM4

NM_002393.5:p.T454M

Associated Papers

Dependence on Mdm2 for Mdm4 inhibition of p53 activity.

Xiong S et al.

Cancer Letters, 2025

Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita.

Sanz-Moreno A et al.

Science Advances, 2025

p53 in the Molecular Circuitry of Bone Marrow Failure Syndromes.

Rakotopare J et al.

International Journal of Molecular Sciences, 2023

p53 Activation in Genetic Disorders: Different Routes to the Same Destination.

Tsai YY et al.

International Journal of Molecular Sciences, 2021

Germline mutation of MDM4, a major p53 regulator, in a familial syndrome of defective telomere maintenance.

Toufektchan E et al.

Science Advances, 2020

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."