Associated Papers
Comparative Analysis of a Dual DNA-RNA Panel and a DNA-Only Panel for Sarcoma: Real-World Data From a Nationwide Genomic Database.
Nakata E et al.
Cancer Science, 2026
Comprehensive genomic landscape of metastatic hormone-sensitive prostate cancer in the Chinese population.
Yang B et al.
World Journal of Surgical Oncology, 2025
Tissue-Specific Genomic Evolution Despite Shared MED12 Mutations in Benign Tumors.
Namkung J et al.
Journal of Clinical Medicine, 2025
Integrating genomic and transcriptome features for characterization and prognostic prediction of angioimmunoblastic T-cell lymphoma.
Wei C et al.
Annals of Hematology, 2025
The Mediator Complex: A Regulatory Hub for Transcriptional Activity of Nuclear Receptors.
Zhou L et al.
Cells, 2025
Activation of FGFR genes by genetic and epigenetic alterations in uterine leiomyomas.
Jokinen V et al.
Bjc Reports, 2025
Differential Expression of Small Non-Coding RNAs in Uterine Leiomyomas.
Chuang TD et al.
International Journal of Molecular Sciences, 2025
Detection of exon2-MED12 mutations in uterine leiomyomas from Syrian patients.
Albitar L et al.
Scientific Reports, 2025
Targeted DNA Sequencing in Diagnosis of Malignant Phyllodes Tumors With Emphasis on Tumors With Keratin and p63 Expression.
Ye J et al.
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2024
Somatic MED12 Mutations in Myometrial Cells.
Li Y et al.
Cells, 2024
Malignant phyllodes tumor with EGFR variant III mutation: A rare case report with immunohistochemical and genomic studies.
Kitazono I et al.
Pathology, Research and Practice, 2024
The Mediator Complex Subunit 12 (MED-12) Gene and Uterine Fibroids: a Systematic Review.
Amendola ILS et al.
Reproductive Sciences (thousand Oaks, Calif.), 2024
The Effect of Race/Ethnicity and MED12 Mutation on the Expression of Long Non-Coding RNAs in Uterine Leiomyoma and Myometrium.
Chuang TD et al.
International Journal of Molecular Sciences, 2024
Gene variants polymorphisms and uterine leiomyoma: an updated review.
Upadhyay S et al.
Frontiers in Genetics, 2024
Mining cancer genomes for change-of-metabolic-function mutations.
Tu KJ et al.
Communications Biology, 2023
RISING STARS: Role of MED12 mutation in the pathogenesis of uterine fibroids.
Ishikawa H et al.
Journal of Molecular Endocrinology, 2023
Molecular Tumor Boards: The Next Step towards Precision Therapy in Cancer Care.
Liu A et al.
Hematology Reports, 2023
Inherited mutations affecting the SRCAP complex are central in moderate-penetrance predisposition to uterine leiomyomas.
Välimäki N et al.
American Journal of Human Genetics, 2023
Differential Expression of MED12-Associated Coding RNA Transcripts in Uterine Leiomyomas.
Chuang TD et al.
International Journal of Molecular Sciences, 2023
MED12 mutations in uterine leiomyomas: prediction of volume reduction by gonadotropin-releasing hormone agonists.
Nagai K et al.
American Journal of Obstetrics and Gynecology, 2023
An integrative approach for exploring the nature of fibroepithelial neoplasms.
Yun J et al.
British Journal of Cancer, 2023
Prevalence and clinical significance of co-existing mutations in MED12 and FH in uterine fibroids of Australian women.
Jamaluddin MFB et al.
Frontiers in Reproductive Health, 2023
Are both distinct epithelial and stromal cells molecular analysis from phyllodes tumors versus fibroadenoma components affected in breast fibroepithelial progression?
Waitzberg ÂFL et al.
Acta Cirurgica Brasileira, 2023
Further characterization of tryptophan metabolism and its dysregulation in fibroids.
Chuang TD et al.
F&s Science, 2022
Analysis of recurrent molecular alterations in phyllodes tumour of breast: insights into prognosis and pathogenesis.
Tsang JY et al.
Pathology, 2022
Single-cell sequencing reveals novel cellular heterogeneity in uterine leiomyomas.
Goad J et al.
Human Reproduction (oxford, England), 2022
A mediator complex subunit 12 gain-of-function mutation induces partial leiomyoma cell properties in human uterine smooth muscle cells.
Takao T et al.
F&s Science, 2022
Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.
Gounder MM et al.
Nature Communications, 2022
Comparison of MED 12 gene mutation and microRNA-124 expression in leiomyoma and myometrium of Turkish patients.
Demiroglu C et al.
Ginekologia Polska, 2022
Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids.
Muralimanoharan S et al.
Scientific Reports, 2022
Therapeutic and immunomodulatory potential of pazopanib in malignant phyllodes tumor.
Ng DYX et al.
Npj Breast Cancer, 2022
Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status.
Hutchinson AP et al.
Reproductive Sciences (thousand Oaks, Calif.), 2022
MED12 exon 2 and TERT promoter mutations in primary and recurrent breast fibroepithelial lesions.
Hu Y et al.
Pathology International, 2021
Long Noncoding RNA MIAT Modulates the Extracellular Matrix Deposition in Leiomyomas by Sponging MiR-29 Family.
Chuang TD et al.
Endocrinology, 2021
Identification and characterization of the mediator kinase-dependent myometrial stem cell phosphoproteome.
Barron L et al.
F&s Science, 2021
Insights into the regulatory role and clinical relevance of mediator subunit, MED12, in human diseases.
Srivastava S et al.
Journal of Cellular Physiology, 2021
Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors.
Aguilar M et al.
The Journal of Pathology, 2021
MED12-Related (Neuro)Developmental Disorders: A Question of Causality.
Plassche SV et al.
Genes, 2021
Integrated mutational landscape analysis of uterine leiomyosarcomas.
Choi J et al.
Proceedings of the National Academy of Sciences of the United States of America, 2021
Clonal dynamics in a composite chronic lymphocytic leukemia and hairy cell leukemia-variant.
Locher M et al.
Genes, Chromosomes & Cancer, 2021
Vitamin D as an effective treatment in human uterine leiomyomas independent of mediator complex subunit 12 mutation.
Corachán A et al.
Fertility and Sterility, 2021
Spectrum of histiocytic neoplasms associated with diverse haematological malignancies bearing the same oncogenic mutation.
Kemps PG et al.
The Journal of Pathology. Clinical Research, 2021
Droplet-digital PCR reveals frequent mutations in TERT promoter region in breast fibroadenomas and phyllodes tumours, irrespective of the presence of MED12 mutations.
Otsuji K et al.
British Journal of Cancer, 2021
Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Li YC et al.
Science Advances, 2021
Morphologic and genetic heterogeneity in breast fibroepithelial lesions-a comprehensive mapping study.
Tan BY et al.
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2020