Associated Papers
Multiple endocrine neoplasia type 1 with neuroglycopenic symptoms with a novel heterozygous MEN1 gene mutation.
Jiang X et al.
World Journal of Surgical Oncology, 2025
Hsp70 incompletely disaggregates misfolded K488X-menin to promote tumourigenesis in a family with multiple endocrine neoplasia type 1.
Zeng Z et al.
Cellular Signalling, 2025
Alternative splicing generates isoform diversity in MEN1.
Ramachandran A et al.
Endocrine Oncology (bristol, England), 2024
Multi-omics analyses of MEN1 missense mutations identify disruption of menin-MLL and menin-JunD interactions as critical requirements for molecular pathogenicity.
Dreijerink KMA et al.
Epigenetics & Chromatin, 2022
Investigating the Effects of Amino Acid Variations in Human Menin.
Biancaniello C et al.
Molecules (basel, Switzerland), 2022
Identification of pathogenic missense mutations using protein stability predictors.
Gerasimavicius L et al.
Scientific Reports, 2020
Systematic analysis of the intersection of disease mutations with protein modifications.
Simpson CM et al.
Bmc Medical Genomics, 2019
Estimating dispensable content in the human interactome.
Ghadie M et al.
Nature Communications, 2019
MEN1 in children and adolescents: Data from patients of a regional referral center for hereditary endocrine tumors.
Vannucci L et al.
Endocrine, 2018
Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase.
Feng Z et al.
Cancer Research, 2017
MEN1 is a melanoma tumor suppressor that preserves genomic integrity by stimulating transcription of genes that promote homologous recombination-directed DNA repair.
Fang M et al.
Molecular and Cellular Biology, 2013
The embryonic transcription factor Hlxb9 is a menin interacting partner that controls pancreatic β-cell proliferation and the expression of insulin regulators.
Shi K et al.
Endocrine-related Cancer, 2013
Impaired transforming growth factor-β (TGF-β) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with multiple endocrine neoplasia type 1 (MEN1).
Canaff L et al.
The Journal of Biological Chemistry, 2012
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Huang J et al.
Nature, 2012
Menin missense mutants encoded by the MEN1 gene that are targeted to the proteasome: restoration of expression and activity by CHIP siRNA.
Canaff L et al.
The Journal of Clinical Endocrinology and Metabolism, 2012
Variable clinical expression in patients with a germline MEN1 disease gene mutation: clues to a genotype-phenotype correlation.
Lips CJ et al.
Clinics (sao Paulo, Brazil), 2012
Correlation of mutant menin stability with clinical expression of multiple endocrine neoplasia type 1 and its incomplete forms.
Shimazu S et al.
Cancer Science, 2011
Unique gene expression profile associated with an early-onset multiple endocrine neoplasia (MEN1)-associated pituitary adenoma.
Farrell WE et al.
The Journal of Clinical Endocrinology and Metabolism, 2011
Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein.
Murai MJ et al.
The Journal of Biological Chemistry, 2011
The menin tumor suppressor protein is phosphorylated in response to DNA damage.
Francis J et al.
Plos One, 2011
The role of germline AIP, MEN1, PRKAR1A, CDKN1B and CDKN2C mutations in causing pituitary adenomas in a large cohort of children, adolescents, and patients with genetic syndromes.
Stratakis CA et al.
Clinical Genetics, 2010
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.
Hughes CM et al.
Molecular Cell, 2004
Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain.
Obungu VH et al.
Oncogene, 2003
The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene.
Sukhodolets KE et al.
Molecular and Cellular Biology, 2003
Menin, the multiple endocrine neoplasia type 1 gene product, exhibits GTP-hydrolyzing activity in the presence of the tumor metastasis suppressor nm23.
Yaguchi H et al.
The Journal of Biological Chemistry, 2002
Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein.
Wautot V et al.
Human Mutation, 2002
Molecular and genetic mechanisms of tumorigenesis in multiple endocrine neoplasia type-1.
Guo SS et al.
Molecular Endocrinology (baltimore, Md.), 2001
The MEN1 gene and associated diseases: an update.
Tsukada T et al.
Endocrine Pathology, 2001
Pituitary macroadenoma in a 5-year-old: an early expression of multiple endocrine neoplasia type 1.
Stratakis CA et al.
The Journal of Clinical Endocrinology and Metabolism, 2000
Loss of heterozygosity in sporadic parathyroid tumours: involvement of chromosome 1 and the MEN1 gene locus in 11q13.
Dwight T et al.
Clinical Endocrinology, 2000
Somatic mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in patients with sporadic, nonfamilial primary hyperparathyroidism.
Sato K et al.
Surgery, 2000
Multiple endocrine neoplasia type 1.
Pannett AA et al.
Endocrine-related Cancer, 1999
Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.
Agarwal SK et al.
Cell, 1999
Parathyroid MEN1 gene mutations in relation to clinical characteristics of nonfamilial primary hyperparathyroidism.
Carling T et al.
The Journal of Clinical Endocrinology and Metabolism, 1998
Germline and somatic mutation of the gene for multiple endocrine neoplasia type 1 (MEN1).
Marx SJ et al.
Journal of Internal Medicine, 1998
Analysis of recurrent germline mutations in the MEN1 gene encountered in apparently unrelated families.
Agarwal SK et al.
Human Mutation, 1998
Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states.
Agarwal SK et al.
Human Molecular Genetics, 1997