Varaico: Literature-Extracted Genetic Variants

Gene:MET
Variant:p.L229F
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MET

NM_000245.4:p.L229F

Associated Papers

Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration.

Feng H et al.

Cancer Biology & Medicine, 2025

Case report: 16-yr life history and genomic evolution of an ER+ HER2- breast cancer.

Xu B et al.

Cold Spring Harbor Molecular Case Studies, 2020

33008833 (PubMed )
Supplement: supp_mcs.a005629_Supplemental_Files_1-5.pdf

Status of Agents Targeting the HGF/c-Met Axis in Lung Cancer.

Miranda O et al.

Cancers, 2018

Maxillary carcinosarcoma: Identification of a novel MET mutation in both carcinomatous and sarcomatous components through next generation sequencing.

Ando M et al.

Head & Neck, 2015

Gastrointestinal malignancies harbor actionable MET exon 14 deletions.

Lee J et al.

Oncotarget, 2015

26375439 (PubMed )
Supplement: oncotarget-06-28211-s003.xlsx › Cosmic_MET

Functional consequence of the MET-T1010I polymorphism in breast cancer.

Liu S et al.

Oncotarget, 2015

The role of the c-Met pathway in lung cancer and the potential for targeted therapy.

Sattler M et al.

Therapeutic Advances in Medical Oncology, 2011

The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors.

Stehr H et al.

Molecular Cancer, 2011

21575214 (PubMed )
Supplement: 1476-4598-10-54-S3.XLS › mutations.txt

Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis.

Benedettini E et al.

The American Journal of Pathology, 2010

Ethnic differences and functional analysis of MET mutations in lung cancer.

Krishnaswamy S et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2009

MET as a target for treatment of chest tumors.

Cipriani NA et al.

Lung Cancer (amsterdam, Netherlands), 2009

Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers.

Onozato R et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2009

Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.

Ma PC et al.

Cancer Research, 2005

MET molecular mechanisms and therapies in lung cancer.

Lawrence RE et al.

Cell Adhesion & Migration, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."