Varaico: Literature-Extracted Genetic Variants

Gene:MET
Variant:p.Y1003N
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MET

NM_000245.4:p.Y1003N

Associated Papers

MET Alterations in Cancer and MET-Targeted Therapy: Detection Strategies, Treatment Efficacy, and Emerging Technologies.

Park J et al.

Targeted Oncology, 2025

Tepotinib for the Treatment of Lung Adenocarcinoma Harboring MET Y1003N Point Mutation: A Case Report.

Umeda Y et al.

Thoracic Cancer, 2025

Whole-Exome Sequencing Reveals Novel Candidate Driver Mutations and Potential Druggable Mutations in Patients with High-Risk Neuroblastoma.

Nokchan N et al.

Journal of Personalized Medicine, 2024

39338204 (PubMed )
Supplement: jpm-14-00950-s001.zip › Supplementary_Table_S5.xlsx › Supplementary_Table_S5.

The Efficacy and Safety of Treating Acquired MET Resistance Through Combinations of Parent and MET Tyrosine Kinase Inhibitors in Patients With Metastatic Oncogene-Driven NSCLC.

Patil T et al.

Jto Clinical and Research Reports, 2024

The rapidly changing field of predictive biomarkers of non-small cell lung cancer.

Tóth LJ et al.

Pathology Oncology Research : Por, 2024

Transforming properties of MET receptor exon 14 skipping can be recapitulated by loss of the CBL ubiquitin ligase binding site.

Fernandes M et al.

Febs Letters, 2023

MET Signaling Pathways, Resistance Mechanisms, and Opportunities for Target Therapies.

Rivas S et al.

International Journal of Molecular Sciences, 2022

36430388 (PubMed )
Supplement: ijms-23-13898-s001.zip › ijms-1981646-supplementary.pdf

Osimertinib and Capmatinib Combination Therapy to Overcome MET Y1003N-Mediated Resistance in EGFR-Mutant NSCLC: A Case Report.

Wilgucki M et al.

Jto Clinical and Research Reports, 2022

SRC Family Kinase Inhibition Targets YES1 and YAP1 as Primary Drivers of Lung Cancer and as Mediators of Acquired Resistance to ALK and Epidermal Growth Factor Receptor Inhibitors.

Sato H et al.

Jco Precision Oncology, 2022

MET-dependent solid tumours - molecular diagnosis and targeted therapy.

Guo R et al.

Nature Reviews. Clinical Oncology, 2020

The DNA walk and its demonstration of deterministic chaos-relevance to genomic alterations in lung cancer.

Hewelt B et al.

Bioinformatics (oxford, England), 2019

Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors.

Frampton GM et al.

Cancer Discovery, 2015

Genomic landscape of non-small cell lung cancer in smokers and never-smokers.

Govindan R et al.

Cell, 2012

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."