Varaico: Literature-Extracted Genetic Variants

Gene:MET
Variant:p.D1010Splc
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MET

NM_000245.4:p.D1010Splc

Associated Papers

Improvement of Diagnostics in NSCLC Patients with MET Exon 14 Mutations Using Complementary DNA/RNA-NGS and Identification of Two Novel Exonic Splicing Mutations.

Urbanska EM et al.

International Journal of Molecular Sciences, 2025

MUTE-Seq: An Ultrasensitive Method for Detecting Low-Frequency Mutations in cfDNA With Engineered Advanced-Fidelity FnCas9.

Ye S et al.

Advanced Materials (deerfield Beach, Fla.), 2025

Discovery of Novel RASGRF2 Fusions as a Therapeutic Target in Lung Adenocarcinoma of Never or Light Smokers.

Terashima Y et al.

Cancer Science, 2025

40734624 (PubMed )
Supplement: CAS-116-2868-s002.xlsx › Table_S3

Clinical Sequence Revealed the Prevalence and Biological Significance of Somatic Pathogenic Variants in Thoracic Cancer: Implications for Germline Status.

Fukushima T et al.

Clinical Lung Cancer, 2025

MET exon 14 skipping mutations in non-small-cell lung cancer a 3 years screening experience.

Dhiab RB et al.

Scientific Reports, 2025

Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration.

Feng H et al.

Cancer Biology & Medicine, 2025

40200811 (PubMed )
Supplement: cbm-22-237-s001.pdf

Safety, Efficacy, and Biomarker Analysis of Crizotinib in MET-Mutated Non-Small Cell Lung Cancer-Results from the Drug Rediscovery Protocol.

Verkerk K et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

Chinese expert consensus on clinical practice of MET detection in non-small cell lung cancer.

Bai Q et al.

Therapeutic Advances in Medical Oncology, 2024

Genomic landscape and tumor mutational features of resected preinvasive to invasive lung adenocarcinoma.

Lin Y et al.

Frontiers in Oncology, 2024

38803537 (PubMed )
Supplement: Table_1.xlsx › Table_S3

Potent antitumor activity of ensartinib in MET exon 14 skipping-mutated non-small cell lung cancer.

Xia Y et al.

Cancer Letters, 2023

Clinical utility of Todai OncoPanel in the setting of approved comprehensive cancer genomic profiling tests in Japan.

Kage H et al.

Cancer Science, 2023

36601953 (PubMed )
Supplement: CAS-114-1710-s001.xlsx › Sup_Table_3

Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer.

Cotto KC et al.

Nature Communications, 2023

36949070 (PubMed )
Supplement: 41467_2023_37266_MOESM8_ESM.xlsx › supplemental_file_6

Optimized Detection of Unknown MET Exon 14 Skipping Mutations in Routine Testing for Patients With Non-Small-Cell Lung Cancer.

Sun R et al.

Jco Precision Oncology, 2023

Relationship between driver gene mutations and clinical pathological characteristics in older lung adenocarcinoma.

Liu X et al.

Frontiers in Oncology, 2023

38023198 (PubMed )
Supplement: Table_1.xlsx › Table_S2

Druggable genomic landscapes of high-grade gliomas.

Ghanem P et al.

Frontiers in Medicine, 2023

38143440 (PubMed )
Supplement: Table_1.xlsx › ST5

MET Signaling Pathways, Resistance Mechanisms, and Opportunities for Target Therapies.

Rivas S et al.

International Journal of Molecular Sciences, 2022

Wide Next-Generation Sequencing Characterization of Young Adults Non-Small-Cell Lung Cancer Patients.

Ulivi P et al.

Cancers, 2022

Variation in targetable genomic alterations in non-small cell lung cancer by genetic ancestry, sex, smoking history, and histology.

Adib E et al.

Genome Medicine, 2022

35428358 (PubMed )
Supplement: 13073_2022_1041_MOESM2_ESM.xlsx › S4_MET_Druggable

Comprehensive analysis of MET mutations in NSCLC patients in a real-world setting.

Ai X et al.

Therapeutic Advances in Medical Oncology, 2022

IDH-mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature.

Chang EK et al.

Brain Pathology (zurich, Switzerland), 2021

33960568 (PubMed )
Supplement: BPA-31-e12959-s004.pdf

Rapid Disease Progression in a Patient with Advanced NSCLC Harboring a Germline MET Exon 14 Skipping Mutation: A Case Report.

Jiao Y et al.

Oncotargets and Therapy, 2021

Identifying Actionable Variants Using Capture-Based Targeted Sequencing in 563 Patients With Non-Small Cell Lung Carcinoma.

Jiang H et al.

Frontiers in Oncology, 2021

35186718 (PubMed )
Supplement: Table_1.xlsx › Supplementary_Table_2

Characterization of MET exon 14 alteration and association with clinical outcomes of crizotinib in Chinese lung cancers.

Yang H et al.

Lung Cancer (amsterdam, Netherlands), 2020

Comprehensive routine diagnostic screening to identify predictive mutations, gene amplifications, and microsatellite instability in FFPE tumor material.

Steeghs EMP et al.

Bmc Cancer, 2020

Highly accurate DNA-based detection and treatment results of MET exon 14 skipping mutations in lung cancer.

Pruis MA et al.

Lung Cancer (amsterdam, Netherlands), 2020

Non-small cell lung cancer with mesenchymal-epithelial transition gene exon 14 skipping mutation treated with crizotinib.

Katakura S et al.

Respirology Case Reports, 2019

Tracking MET de-addiction in lung cancer: A road towards the oncogenic target.

Pilotto S et al.

Cancer Treatment Reviews, 2017

MET Exon 14 Skipping Mutations in Lung Adenocarcinoma: Clinicopathologic Implications and Prognostic Values.

Lee GD et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2017

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden.

Chalmers ZR et al.

Genome Medicine, 2017

28420421 (PubMed )
Supplement: 13073_2017_424_MOESM7_ESM.xlsx › Sheet1

Characterization of 298 Patients with Lung Cancer Harboring MET Exon 14 Skipping Alterations.

Schrock AB et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2016

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."