Varaico: Literature-Extracted Genetic Variants

Gene:MET
Variant:p.D1010Splc
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MET

NM_000245.4:p.D1010Splc

Associated Papers

MEK inhibitor Mirdametinib promotes fracture healing in osteofibrous dysplasia RASopathy.

Khalid A et al.

The Journal of Clinical Investigation, 2026

Discovery of Novel RASGRF2 Fusions as a Therapeutic Target in Lung Adenocarcinoma of Never or Light Smokers.

Terashima Y et al.

Cancer Science, 2025

40734624 (PubMed )
Supplement: CAS-116-2868-s002.xlsx › Table_S3

Clinical Sequence Revealed the Prevalence and Biological Significance of Somatic Pathogenic Variants in Thoracic Cancer: Implications for Germline Status.

Fukushima T et al.

Clinical Lung Cancer, 2025

Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration.

Feng H et al.

Cancer Biology & Medicine, 2025

40200811 (PubMed )
Supplement: cbm-22-237-s001.pdf

Clinical implementation of next-generation sequencing testing and genomically-matched therapy: a real-world data in a tertiary hospital.

Kim JW et al.

Scientific Reports, 2025

Safety, Efficacy, and Biomarker Analysis of Crizotinib in MET-Mutated Non-Small Cell Lung Cancer-Results from the Drug Rediscovery Protocol.

Verkerk K et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

Incidental pathogenic germline alterations detected through liquid biopsy in patients with solid tumors: prevalence, clinical utility and implications.

Laguna JC et al.

British Journal of Cancer, 2024

Genomic Landscape of Pulmonary Sarcomatoid Carcinoma.

Kwon HJ et al.

Cancer Research and Treatment, 2024

37973906 (PubMed )
Supplement: crt-2023-764-Supplementary-Table-S4.pdf

Chinese expert consensus on clinical practice of MET detection in non-small cell lung cancer.

Bai Q et al.

Therapeutic Advances in Medical Oncology, 2024

Cerebrospinal fluid circulating tumor DNA contributes to the detection and characterization of leptomeningeal metastasis in non-small cell lung cancer.

Miao Q et al.

Journal of Neuro-oncology, 2023

Potent antitumor activity of ensartinib in MET exon 14 skipping-mutated non-small cell lung cancer.

Xia Y et al.

Cancer Letters, 2023

Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer.

Cotto KC et al.

Nature Communications, 2023

36949070 (PubMed )
Supplement: 41467_2023_37266_MOESM8_ESM.xlsx › supplemental_file_6

Optimized Detection of Unknown MET Exon 14 Skipping Mutations in Routine Testing for Patients With Non-Small-Cell Lung Cancer.

Sun R et al.

Jco Precision Oncology, 2023

MET Signaling Pathways, Resistance Mechanisms, and Opportunities for Target Therapies.

Rivas S et al.

International Journal of Molecular Sciences, 2022

Liquid biopsy using ascitic fluid and pleural effusion supernatants for genomic profiling in gastrointestinal and lung cancers.

Wu H et al.

Bmc Cancer, 2022

36167530 (PubMed )
Supplement: 12885_2022_9922_MOESM5_ESM.xlsx › Sheet1

Does histological assessment accurately distinguish separate primary lung adenocarcinomas from intrapulmonary metastases? A study of paired resected lung nodules in 32 patients using a routine next-generation sequencing panel for driver mutations.

Bruehl FK et al.

Journal of Clinical Pathology, 2022

Variation in targetable genomic alterations in non-small cell lung cancer by genetic ancestry, sex, smoking history, and histology.

Adib E et al.

Genome Medicine, 2022

35428358 (PubMed )
Supplement: 13073_2022_1041_MOESM2_ESM.xlsx › S4_MET_Druggable

Molecular cytopathology diagnosis of a lung neoplasm: Case report of an unusual non-small cell carcinoma with MET exon 14 skipping mutation.

Hosseini SM et al.

Diagnostic Cytopathology, 2021

Long-term efficacy of immune checkpoint inhibitors in non-small cell lung cancer patients harboring MET exon 14 skipping mutations.

Kato Y et al.

International Journal of Clinical Oncology, 2021

Frequency of MET exon 14 skipping mutations in non-small cell lung cancer according to technical approach in routine diagnosis: results from a real-life cohort of 2,369 patients.

Champagnac A et al.

Journal of Thoracic Disease, 2020

Highly accurate DNA-based detection and treatment results of MET exon 14 skipping mutations in lung cancer.

Pruis MA et al.

Lung Cancer (amsterdam, Netherlands), 2020

Clinical and analytical validation of FoundationOne Liquid CDx, a novel 324-Gene cfDNA-based comprehensive genomic profiling assay for cancers of solid tumor origin.

Woodhouse R et al.

Plos One, 2020

32976510 (PubMed )
Supplement: pone.0237802.s009.zip › Table_9_Accuracy_Short_Variant_Line_Data.xlsx › sheet_1

Lung Cancer Patients with Germline Mutations Detected by Next-Generation Sequencing and/or Liquid Biopsy.

Shukuya T et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2018

MET Exon 14 Alterations and New Resistance Mutations to Tyrosine Kinase Inhibitors: Risk of Inadequate Detection with Current Amplicon-Based NGS Panels.

Poirot B et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2017

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."