Varaico: Literature-Extracted Genetic Variants

Gene:MET
Variant:p.H1106D
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MET

NM_000245.4:p.H1106D

Associated Papers

Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration.

Feng H et al.

Cancer Biology & Medicine, 2025

40200811 (PubMed )
Supplement: cbm-22-237-s001.pdf

Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors.

Pecci F et al.

Cancer Discovery, 2024

MET Signaling Pathways, Resistance Mechanisms, and Opportunities for Target Therapies.

Rivas S et al.

International Journal of Molecular Sciences, 2022

36430388 (PubMed )
Supplement: ijms-23-13898-s001.zip › ijms-1981646-supplementary.pdf

MET-dependent solid tumours - molecular diagnosis and targeted therapy.

Guo R et al.

Nature Reviews. Clinical Oncology, 2020

Targeting MET Dysregulation in Cancer.

Recondo G et al.

Cancer Discovery, 2020

Clinical and analytical validation of FoundationOne Liquid CDx, a novel 324-Gene cfDNA-based comprehensive genomic profiling assay for cancers of solid tumor origin.

Woodhouse R et al.

Plos One, 2020

32976510 (PubMed )
Supplement: pone.0237802.s009.zip › Table_9_Accuracy_Short_Variant_Line_Data.xlsx › sheet_1

Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer.

Miao W et al.

Cancer Science, 2019

Exon 14 Deleted MET Receptor as a New Biomarker and Target in Cancers.

Cortot AB et al.

Journal of the National Cancer Institute, 2017

The role of the c-Met pathway in lung cancer and the potential for targeted therapy.

Sattler M et al.

Therapeutic Advances in Medical Oncology, 2011

Computational modeling of structurally conserved cancer mutations in the RET and MET kinases: the impact on protein structure, dynamics, and stability.

Dixit A et al.

Biophysical Journal, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."