Varaico: Literature-Extracted Genetic Variants

Gene:MET
Variant:p.V1220I
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MET

NM_000245.4:p.V1220I

Associated Papers

Discovery of Novel RASGRF2 Fusions as a Therapeutic Target in Lung Adenocarcinoma of Never or Light Smokers.

Terashima Y et al.

Cancer Science, 2025

40734624 (PubMed )
Supplement: CAS-116-2868-s002.xlsx › Table_S3

Advances in the diagnosis and treatment of MET-variant digestive tract tumors.

Zhang C et al.

World Journal of Gastrointestinal Oncology, 2024

Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors.

Pecci F et al.

Cancer Discovery, 2024

Recording and classifying MET receptor mutations in cancers.

Guérin C et al.

Elife, 2024

MET Signaling Pathways, Resistance Mechanisms, and Opportunities for Target Therapies.

Rivas S et al.

International Journal of Molecular Sciences, 2022

36430388 (PubMed )
Supplement: ijms-23-13898-s001.zip › ijms-1981646-supplementary.pdf

Novel germline MET pathogenic variants in French patients with papillary renal cell carcinomas type I.

Sebai M et al.

Human Mutation, 2022

Landscape and Clonal Dominance of Co-occurring Genomic Alterations in Non-Small-Cell Lung Cancer Harboring MET Exon 14 Skipping.

Le X et al.

Jco Precision Oncology, 2021

Identification of pathogenic missense mutations using protein stability predictors.

Gerasimavicius L et al.

Scientific Reports, 2020

32958805 (PubMed )
Supplement: 41598_2020_72404_MOESM2_ESM.xlsx › ClinVar

MET-dependent solid tumours - molecular diagnosis and targeted therapy.

Guo R et al.

Nature Reviews. Clinical Oncology, 2020

LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models.

Yan SB et al.

Investigational New Drugs, 2013

The role of the c-Met pathway in lung cancer and the potential for targeted therapy.

Sattler M et al.

Therapeutic Advances in Medical Oncology, 2011

Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors.

Timofeevski SL et al.

Biochemistry, 2009

Biochemical basis for the functional switch that regulates hepatocyte growth factor receptor tyrosine kinase activation.

Sheth PR et al.

Biochemistry, 2008

Different point mutations in the met oncogene elicit distinct biological properties.

Giordano S et al.

Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."