Varaico: Literature-Extracted Genetic Variants

Gene:MET
Variant:p.Y1230N
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MET

NM_000245.4:p.Y1230N

Associated Papers

Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration.

Feng H et al.

Cancer Biology & Medicine, 2025

Real-world experience with circulating tumor DNA in cerebrospinal fluid from patients with central nervous system tumors.

Hickman RA et al.

Acta Neuropathologica Communications, 2024

Savolitinib conferred sensitivity in a patient with D1228H mutation-induced capmatinib-resistant MET exon 14 skipping mutated lung adenocarcinoma.

Li X et al.

Journal of Cancer Research and Clinical Oncology, 2024

Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors.

Pecci F et al.

Cancer Discovery, 2024

38564707 (PubMed )
Supplement: cd-23-1217_supplementary_table_11_suppst11.pdf

Genomic mapping of metastatic organotropism in lung adenocarcinoma.

Lengel HB et al.

Cancer Cell, 2023

Mutations in the MET tyrosine kinase domain and resistance to tyrosine kinase inhibitors in non-small-cell lung cancer.

Yao Y et al.

Respiratory Research, 2023

MET Signaling Pathways, Resistance Mechanisms, and Opportunities for Target Therapies.

Rivas S et al.

International Journal of Molecular Sciences, 2022

36430388 (PubMed )
Supplement: ijms-23-13898-s001.zip › ijms-1981646-supplementary.pdf

Combination of Type I and Type II MET Tyrosine Kinase Inhibitors as Therapeutic Approach to Prevent Resistance.

Bahcall M et al.

Molecular Cancer Therapeutics, 2022

Identification of a EML4-ALK exon 19 fusion variant in lung adenocarcinoma and alectinib resistance.

Liu D et al.

Lung Cancer (amsterdam, Netherlands), 2021

Genomic and clinical characteristics of MET exon14 alterations in a large cohort of Chinese cancer patients revealed distinct features and a novel resistance mechanism for crizotinib.

Cheng T et al.

Journal of Cancer, 2021

Resistance to TRK inhibition mediated by convergent MAPK pathway activation.

Cocco E et al.

Nature Medicine, 2019

31406350 (PubMed )
Supplement: NIHMS1533563-supplement-1.xlsx › Patient_3

A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients.

Tiedt R et al.

Cancer Research, 2011

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