Varaico: Literature-Extracted Genetic Variants

Gene:MET
Variant:p.Y1230*
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MET

NM_000245.4:p.Y1230*

Associated Papers

MET Alterations in Cancer and MET-Targeted Therapy: Detection Strategies, Treatment Efficacy, and Emerging Technologies.

Park J et al.

Targeted Oncology, 2025

A comprehensive database for identifying and interpreting ctDNA driver genes and variants in cancer.

Wang Y et al.

Scientific Data, 2025

40670358 (PubMed )
Supplement: 41597_2025_5550_MOESM1_ESM.xls › Table_S5

Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration.

Feng H et al.

Cancer Biology & Medicine, 2025

Prognostic and predictive biomarkers with therapeutic targets in nonsmall-cell lung cancer: A 2023 update on current development, evidence, and recommendation.

Chung C et al.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners, 2025

Resistance Mutation Profiles Associated with Current Treatments for Epidermal Growth Factor Receptor-Mutated Non-Small-Cell Lung Cancer in the United States: A Systematic Literature Review.

Vadagam P et al.

Current Oncology (toronto, Ont.), 2025

40277748 (PubMed )
Supplement: curroncol-32-00191-s001.zip › curroncol-3409061-supplementary.pdf

Advances in clinical research of MET exon 14 skipping mutations in non-small cell lung cancer.

Wang M et al.

Journal of Cancer Research and Clinical Oncology, 2025

Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors.

Pecci F et al.

Cancer Discovery, 2024

MYC amplification-conferred primary resistance to capmatinib in a MET-amplified NSCLC patient: a case report.

Choi W et al.

Translational Lung Cancer Research, 2022

Foretinib can overcome common on-target resistance mutations after capmatinib/tepotinib treatment in NSCLCs with MET exon 14 skipping mutation.

Fujino T et al.

Journal of Hematology & Oncology, 2022

Brief Report: Heterogeneity of Acquired Resistance Mechanisms to Osimertinib and Savolitinib.

Lim SM et al.

Jto Clinical and Research Reports, 2021

Lung Cancer with MET exon 14 Skipping Mutation: Genetic Feature, Current Treatments, and Future Challenges.

Fujino T et al.

Lung Cancer (auckland, N.z.), 2021

Case Report: Sequential Combination Targeted Therapy With Type I and II MET Inhibitors in a Metastatic EGFR-Mutated, MET-Amplified NSCLC Patient With Acquired MET Y1230H Mutation.

Cai B et al.

Frontiers in Oncology, 2021

Acquired Resistance to Osimertinib Plus Savolitinib Is Mediated by MET-D1228 and MET-Y1230 Mutations in EGFR-Mutated MET-Amplified Lung Cancer.

Piper-Vallillo AJ et al.

Jto Clinical and Research Reports, 2020

[Chinese Expert Consensus on Next Generation Sequencing Diagnosis 
for Non-small Cell Lung Cancer (2020 Edition)].

Unknown Author

Zhongguo Fei Ai Za Zhi = Chinese Journal of Lung Cancer, 2020

Tepotinib in Non-Small-Cell Lung Cancer with MET Exon 14 Skipping Mutations.

Paik PK et al.

The New England Journal of Medicine, 2020

Targeting MET Dysregulation in Cancer.

Recondo G et al.

Cancer Discovery, 2020

Management of Non-small Cell Lung Cancer Patients with MET Exon 14 Skipping Mutations.

Huang C et al.

Current Treatment Options in Oncology, 2020

Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer.

Rotow JK et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2020

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."