Varaico: Literature-Extracted Genetic Variants

Gene:METTL14
Variant:p.R298P
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METTL14

NM_020961.4:p.R298P

Associated Papers

Single-nucleotide m⁶A mapping uncovers redundant YTHDF function in planarian progenitor fate selection.

Yesharim Y et al.

The Embo Journal, 2026

Mechanosensitive snoRNA-like circular RNA sno-circCNOT1 drives endothelial dysfunction and atherosclerosis.

Bi L et al.

Theranostics, 2026

RMVar 2.0: an updated database of functional variants in RNA modifications.

Huang Y et al.

Nucleic Acids Research, 2025

39436017 (PubMed )
Supplement: gkae924_supplemental_files.zip › Table_S1.xlsx › Table_S2

Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14.

Zhang C et al.

Science Advances, 2024

The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs).

Zhang L et al.

Elife, 2024

39688960 (PubMed )
Supplement: elife-99340-supp1.xlsx › CDN.Missense.gnomad

METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer.

Bai X et al.

Journal of Experimental & Clinical Cancer Research : Cr, 2024

Decoding the molecular symphony: interactions between the m6A and p53 signaling pathways in cancer.

Shoemaker R et al.

Nar Cancer, 2024

New insights for gynecological cancer therapies: from molecular mechanisms and clinical evidence to future directions.

Zhang C et al.

Cancer Metastasis Reviews, 2023

A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth.

Miyake K et al.

Cell Reports, 2023

METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53-wild-type cells.

Hou Y et al.

Embo Reports, 2023

Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14.

Zhang C et al.

Biorxiv : the Preprint Server for Biology, 2023

The potential role of methyltransferase-like 5 in deficient mismatch repair of uterine corpus endometrial carcinoma.

Liu X et al.

Bioengineered, 2022

RNA Epigenetics: Fine-Tuning Chromatin Plasticity and Transcriptional Regulation, and the Implications in Human Diseases.

Willbanks A et al.

Genes, 2021

Spatially interacting phosphorylation sites and mutations in cancer.

Huang KL et al.

Nature Communications, 2021

33875650 (PubMed )
Supplement: 41467_2021_22481_MOESM4_ESM.xlsx › TableS6.RecurrenceClusters

RMVar: an updated database of functional variants involved in RNA modifications.

Luo X et al.

Nucleic Acids Research, 2021

33021671 (PubMed )
Supplement: gkaa811_supplemental_files.zip › Table_S1.xlsx › Table_S2

The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.

Punta M et al.

Frontiers in Immunology, 2020

33133066 (PubMed )
Supplement: Table_1.xlsx › Drivers-not-HR

Systematic analysis of the intersection of disease mutations with protein modifications.

Simpson CM et al.

Bmc Medical Genomics, 2019

31345222 (PubMed )
Supplement: 12920_2019_543_MOESM2_ESM.xlsx › S2

Next-Generation Sequencing.

Le Gallo M et al.

Advances in Experimental Medicine and Biology, 2017

Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer.

Gnad F et al.

Bmc Genomics, 2015

26110843 (PubMed )
Supplement: 1471-2164-16-S8-S5-S7.xls › RecurrentMutations

Novel genetic targets in endometrial cancer.

Bell DW

Expert Opinion on Therapeutic Targets, 2014

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."