Varaico: Literature-Extracted Genetic Variants

Gene:METTL3
Variant:p.D395A
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METTL3

NM_019852.5:p.D395A

Associated Papers

RNA m6A Methylation Promotes Tumor Development and WASF3 Translation in Esophageal Squamous Cell Carcinoma.

Shang QX et al.

Medcomm, 2025

41127505 (PubMed )
Supplement: MCO2-6-e70443-s001.docx

m6A modulates RAN translation from CAG repeat expansion RNA.

Sun Y et al.

Aggregate (hoboken, N.j.), 2025

Synonymous mutations promote tumorigenesis by disrupting m6A-dependent mRNA metabolism.

Lan Y et al.

Cell, 2025

m6A modification enhances the stability of CDC25A promotes tumorigenicity of esophagogastric junction adenocarcinoma via cell cycle.

Pan Y et al.

International Journal of Biological Sciences, 2024

The Mettl3 epitranscriptomic writer amplifies p53 stress responses.

Raj N et al.

Molecular Cell, 2022

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding.

Wang W et al.

Nature Communications, 2021

34155197 (PubMed )
Supplement: 41467_2021_23501_MOESM1_ESM.pdf

mTORC1 promotes cell growth via m6A-dependent mRNA degradation.

Cho S et al.

Molecular Cell, 2021

METTL3-Mediated N6-Methyladenosine Modification Is Involved in the Dysregulation of NRIP1 Expression in Down Syndrome.

Shi W et al.

Frontiers in Cell and Developmental Biology, 2021

m6A Facilitates eIF4F-Independent mRNA Translation.

Coots RA et al.

Molecular Cell, 2017

m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways.

Li HB et al.

Nature, 2017

Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex.

Wang X et al.

Nature, 2016

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."