Varaico: Literature-Extracted Genetic Variants

Gene:MGMT
Variant:p.P140A
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MGMT

NM_002412.5:p.P140A

Associated Papers

Identifying active and inhibitor-resistant MGMT variants for gene therapy.

Cheong A et al.

American Journal of Human Genetics, 2025

O6-methylguanine-DNA-methyltransferase expression and gene polymorphisms in relation to chemotherapeutic response in metastatic melanoma.

Ma S et al.

British Journal of Cancer, 2003

[Mutation of human O6-alkylguanine-DNA alkyltransferase confers resistance to O6-benzylguanine].

Wan Y et al.

Zhonghua Zhong Liu Za Zhi [chinese Journal of Oncology], 2000

Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase.

Williams DA et al.

Bone Marrow Transplantation, 2000

Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.

Daniels DS et al.

The Embo Journal, 2000

Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment.

Maze R et al.

The Journal of Pharmacology and Experimental Therapeutics, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."