Associated Papers
Identifying active and inhibitor-resistant MGMT variants for gene therapy.
Cheong A et al.
American Journal of Human Genetics, 2025
Evaluation of mutations on O6-methylguanine methyl transferase structure and its interactions: molecular dynamics simulation study.
Gharouni M et al.
Journal of Biomolecular Structure & Dynamics, 2025
Mutation analysis of the TERT gene in ovarian cancer patients of the Turkish population by next generation sequencing method.
Capar Gorali B et al.
Cellular and Molecular Biology (noisy-le-grand, France), 2023
Brain radiotoxicity-related 15CAcBRT gene expression signature predicts survival prognosis of glioblastoma patients.
Reyes-González J et al.
Neuro-oncology, 2023
Somatic Double Inactivation of NF1 Associated with NF1-Related Pectus Excavatum Deformity.
Chelleri C et al.
Human Mutation, 2023
Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality.
Lamb KL et al.
Molecular Carcinogenesis, 2014
Splice site and Germline variations of the MGMT gene in Esophageal cancer from Kashmir Valley: India.
Shah MA et al.
International Journal of Health Sciences, 2013
Temozolomide-induced severe myelosuppression: analysis of clinically associated polymorphisms in two patients.
Sylvester RK et al.
Anti-cancer Drugs, 2011
O6-methylguanine-DNA methyltransferase gene coding region polymorphisms and oral cancer risk.
Huang SH et al.
Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2010
Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer.
Zhang Z et al.
Dna Repair, 2010
Effects of amino acid substitution polymorphisms of two DNA methyltransferases on susceptibility to sporadic colorectal cancer.
Khatami F et al.
Asian Pacific Journal of Cancer Prevention : Apjcp, 2009
DNA damage and repair: from molecular mechanisms to health implications.
Altieri F et al.
Antioxidants & Redox Signaling, 2008
Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase.
Fang Q et al.
Biochemical Pharmacology, 2008
Human variants of O6-alkylguanine-DNA alkyltransferase.
Pegg AE et al.
Dna Repair, 2007
DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy.
Tubbs JL et al.
Dna Repair, 2007
Lung cancer risk and variation in MGMT activity and sequence.
Povey AC et al.
Dna Repair, 2007
Pharmacogenetics of cancer chemotherapy.
Abraham J et al.
Biochimica Et Biophysica Acta, 2006
Molecular modeling of O6-methylguanine-DNA methyltransferase mutant proteins encoded by single nucleotide polymorphisms.
Schwarzl SM et al.
International Journal of Molecular Medicine, 2005
Pharmacogenetics for individualized cancer chemotherapy.
Efferth T et al.
Pharmacology & Therapeutics, 2005
The L84F and the I143V polymorphisms in the O6-methylguanine-DNA-methyltransferase (MGMT) gene increase human sensitivity to the genotoxic effects of the tobacco-specific nitrosamine carcinogen NNK.
Hill CE et al.
Pharmacogenetics and Genomics, 2005
Predicting drug response and toxicity based on gene polymorphisms.
Robert J et al.
Critical Reviews in Oncology/hematology, 2005
Genetic susceptibility and gastric cancer risk.
González CA et al.
International Journal of Cancer, 2002
Molecular genetics of cancer susceptibility.
Brockmöller J et al.
Pharmacology, 2000
Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.
Daniels DS et al.
The Embo Journal, 2000
Redesigning the substrate specificity of human O(6)-alkylguanine-DNA alkyltransferase. Mutants with enhanced repair of O(4)-methylthymine.
Encell LP et al.
Biochemistry, 1999
Leukocyte O6-alkylguanine-DNA alkyltransferase from human donors is uniformly sensitive to O6-benzylguanine.
Gerson SL et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 1999