Associated Papers
Identifying active and inhibitor-resistant MGMT variants for gene therapy.
Cheong A et al.
American Journal of Human Genetics, 2025
Evaluation of mutations on O6-methylguanine methyl transferase structure and its interactions: molecular dynamics simulation study.
Gharouni M et al.
Journal of Biomolecular Structure & Dynamics, 2025
Integrative Computational Analysis of Common EXO5 Haplotypes: Impact on Protein Dynamics, Genome Stability, and Cancer Progression.
Mazza F et al.
Journal of Chemical Information and Modeling, 2025
Host repair polymorphisms and H. pylori genes in gastric disease outcomes: Who are the guardian and villains?
Maria de Oliveira Barboza M et al.
Gene, 2025
Mutation analysis of the TERT gene in ovarian cancer patients of the Turkish population by next generation sequencing method.
Capar Gorali B et al.
Cellular and Molecular Biology (noisy-le-grand, France), 2023
Genetic and epigenetic alterations in MGMT gene and correlation with concomitant chemoradiotherapy (CRT) in cervical cancer.
Gupta MK et al.
Journal of Cancer Research and Clinical Oncology, 2023
Brain radiotoxicity-related 15CAcBRT gene expression signature predicts survival prognosis of glioblastoma patients.
Reyes-González J et al.
Neuro-oncology, 2023
Temozolomide-induced myelotoxicity and single nucleotide polymorphisms in the MGMT gene in patients with adult diffuse glioma: a single-institutional pharmacogenetic study.
Moitra P et al.
Journal of Neuro-oncology, 2022
Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases.
FitzGerald LM et al.
Prostate Cancer and Prostatic Diseases, 2018
MGMT gene variants, temozolomide myelotoxicity and glioma risk. A concise literature survey including an illustrative case.
Altinoz MA et al.
Journal of Chemotherapy (florence, Italy), 2017
The intricate interplay between MSI and polymorphisms of DNA repair enzymes in gastric cancer H.pylori associated.
Silva-Fernandes IJL et al.
Mutagenesis, 2017
Investigation of DNA repair-related SNPs underlying susceptibility to papillary thyroid carcinoma reveals MGMT as a novel candidate gene in Belarusian children exposed to radiation.
Lonjou C et al.
Bmc Cancer, 2017
Clinical and Genetic Factors Associated With Severe Hematological Toxicity in Glioblastoma Patients During Radiation Plus Temozolomide Treatment: A Prospective Study.
Lombardi G et al.
American Journal of Clinical Oncology, 2015
Genetic Association Between Angiotensinogen Polymorphisms and Lung Cancer Risk.
Wang H et al.
Medicine, 2015
Deletion of the MGMT gene in familial melanoma.
Appelqvist F et al.
Genes, Chromosomes & Cancer, 2014
MGMT gene silencing by promoter hypermethylation in gastric cancer in a high incidence area.
Yousuf A et al.
Cellular Oncology (dordrecht, Netherlands), 2014
Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality.
Lamb KL et al.
Molecular Carcinogenesis, 2014
Identification of methylguanine methyltransferase polymorphisms as genetic markers of individual susceptibility to therapy-related myeloid neoplasms.
Dubois J et al.
European Journal of Cancer (oxford, England : 1990), 2014
Potentially functional SNPs (pfSNPs) as novel genomic predictors of 5-FU response in metastatic colorectal cancer patients.
Wang J et al.
Plos One, 2014
Splice site and Germline variations of the MGMT gene in Esophageal cancer from Kashmir Valley: India.
Shah MA et al.
International Journal of Health Sciences, 2013
The polymorphisms in the MGMT gene and the risk of cancer: a meta-analysis.
Du L et al.
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 2013
The T genotype of the MGMT C>T (rs16906252) enhancer single-nucleotide polymorphism (SNP) is associated with promoter methylation and longer survival in glioblastoma patients.
McDonald KL et al.
European Journal of Cancer (oxford, England : 1990), 2013
DNA mismatch repair network gene polymorphism as a susceptibility factor for pancreatic cancer.
Dong X et al.
Molecular Carcinogenesis, 2012
SNP-SNP interactions between DNA repair genes were associated with breast cancer risk in a Korean population.
Han W et al.
Cancer, 2012
Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia.
Shi JY et al.
International Journal of Cancer, 2011
Temozolomide-induced severe myelosuppression: analysis of clinically associated polymorphisms in two patients.
Sylvester RK et al.
Anti-cancer Drugs, 2011
Genotoxic thresholds, DNA repair, and susceptibility in human populations.
Jenkins GJ et al.
Toxicology, 2010
O6-methylguanine-DNA methyltransferase gene coding region polymorphisms and oral cancer risk.
Huang SH et al.
Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2010
Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer.
Zhang Z et al.
Dna Repair, 2010
Effects of O6-methylguanine-DNA methyltransferase (MGMT) polymorphisms on cancer: a meta-analysis.
Zhong Y et al.
Mutagenesis, 2010
DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma.
Rajaraman P et al.
Neuro-oncology, 2010
Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran.
Akbari MR et al.
Cancer Research, 2009
[Genetic susceptibility of single nucleotide polymorphism in MGMT to non-Hodgkin lymphoma].
Yang F et al.
Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, 2009
Genetic variations in esophageal cancer risk and prognosis.
Cheung WY et al.
Gastroenterology Clinics of North America, 2009
The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity.
Remington M et al.
Neuro-oncology, 2009
Promoter methylation and polymorphisms of the MGMT gene in glioblastomas: a population-based study.
Zawlik I et al.
Neuroepidemiology, 2009
International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.
Hung RJ et al.
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2008
Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma.
Doecke J et al.
International Journal of Cancer, 2008
Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6-alkylguanine-DNA alkyltransferase.
Crosbie PA et al.
International Journal of Cancer, 2008
Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase.
Fang Q et al.
Biochemical Pharmacology, 2008
Inherited predisposition of lung cancer: a hierarchical modeling approach to DNA repair and cell cycle control pathways.
Hung RJ et al.
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2007
Genetic variation in the DNA repair genes is predictive of outcome in lung cancer.
Matakidou A et al.
Human Molecular Genetics, 2007
MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer.
Ogino S et al.
Carcinogenesis, 2007
Polymorphisms in DNA repair genes and risk of non-Hodgkin's lymphoma in New South Wales, Australia.
Shen M et al.
Haematologica, 2007
The L84F polymorphism in the O6-Methylguanine-DNA-Methyltransferase (MGMT) gene is associated with increased hypoxanthine phosphoribosyltransferase (HPRT) mutant frequency in lymphocytes of tobacco smokers.
Hill CE et al.
Pharmacogenetics and Genomics, 2007
Human variants of O6-alkylguanine-DNA alkyltransferase.
Pegg AE et al.
Dna Repair, 2007
DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy.
Tubbs JL et al.
Dna Repair, 2007
Genetic association and functional studies of major polymorphic variants of MGMT.
Bugni JM et al.
Dna Repair, 2007
Lung cancer risk and variation in MGMT activity and sequence.
Povey AC et al.
Dna Repair, 2007