Varaico: Literature-Extracted Genetic Variants

Gene:MLH1
Variant:p.V4V
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MLH1

NM_000249.4:p.V4V

Associated Papers

Clinicopathological, molecular, and prognostic features of colorectal carcinomas with KRAS c.34G>T (p.G12C) mutation.

Ugai S et al.

Cancer Science, 2024

Japanese Society of Medical Oncology clinical guidelines: Molecular testing for colorectal cancer treatment, 5th edition.

Bando H et al.

Cancer Science, 2024

38263580 (PubMed )
Supplement: CAS-115-1014-s001.docx

Molecular profiling and feasibility using a comprehensive hybrid capture panel on a consecutive series of non-small-cell lung cancer patients from a single centre.

Mosteiro M et al.

Esmo Open, 2023

Molecular and Sociodemographic Colorectal Cancer Disparities in Latinos Living in Puerto Rico.

Perez-Mayoral J et al.

Genes, 2023

Loss of HES1 Expression is Associated with Extracellular Matrix Remodeling and Tumor Immune Suppression in KRAS Mutant Colon Adenocarcinomas.

Wang L et al.

Research Square, 2023

Gene fusions and oncogenic mutations in MLH1 deficient and BRAFV600E wild-type colorectal cancers.

Ukkola I et al.

Virchows Archiv : an International Journal of Pathology, 2022

35237889 (PubMed )
Supplement: 428_2022_3302_MOESM1_ESM.pdf

Mismatch Repair Deficiency and Somatic Mutations in Human Sinonasal Tumors.

Hieggelke L et al.

Cancers, 2021

Mutation status and prognostic value of KRAS and NRAS mutations in Moroccan colon cancer patients: A first report.

El Agy F et al.

Plos One, 2021

Genomic profiling of primary histiocytic sarcoma reveals two molecular subgroups.

Egan C et al.

Haematologica, 2020

Comprehensive Analysis of PTEN in Primary Cutaneous Melanoma.

Němejcová K et al.

Folia Biologica, 2020

A comprehensive evaluation of pathogenic mutations in primary cutaneous melanomas, including the identification of novel loss-of-function variants.

Ticha I et al.

Scientific Reports, 2019

A KRAS wild type mutational status confers a survival advantage in pancreatic ductal adenocarcinoma.

Windon AL et al.

Journal of Gastrointestinal Oncology, 2018

Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma.

Dong ZY et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2017

Genetic heterogeneity in synchronous colorectal cancers impacts genotyping approaches and therapeutic strategies.

Jesinghaus M et al.

Genes, Chromosomes & Cancer, 2016

Genomic profile of pseudomyxoma peritonei analyzed using next-generation sequencing and immunohistochemistry.

Nummela P et al.

International Journal of Cancer, 2015

The molecular basis of rectal cancer.

Shiller M et al.

Clinics in Colon and Rectal Surgery, 2015

KRAS and BRAF Mutation Detection: Is Immunohistochemistry a Possible Alternative to Molecular Biology in Colorectal Cancer?

Piton N et al.

Gastroenterology Research and Practice, 2015

KRAS codon 12 and 13 mutations in relation to disease-free survival in BRAF-wild-type stage III colon cancers from an adjuvant chemotherapy trial (N0147 alliance).

Yoon HH et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2014

Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review.

Imamura Y et al.

Molecular Cancer, 2014

Clinical utility of KRAS and BRAF mutations in a cohort of patients with colorectal neoplasms submitted for microsatellite instability testing.

Cushman-Vokoun AM et al.

Clinical Colorectal Cancer, 2013

MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes.

Donehower LA et al.

The Journal of Pathology, 2013

Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wild-type colorectal cancers.

Imamura Y et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2012

Clinically important molecular features of Peruvian colorectal tumours: high prevalence of DNA mismatch repair deficiency and low incidence of KRAS mutations.

Egoavil CM et al.

Pathology, 2011

MSH6 and MUTYH deficiency is a frequent event in early-onset colorectal cancer.

Giráldez MD et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2010

High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer.

Simi L et al.

American Journal of Clinical Pathology, 2008

Patterns of K-ras mutation in colorectal carcinomas from Iran and Italy (a Gruppo Oncologico dell'Italia Meridionale study): influence of microsatellite instability status and country of origin.

Bishehsari F et al.

Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2006

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."