Varaico: Literature-Extracted Genetic Variants

Gene:MLH1
Variant:p.S477A
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MLH1

NM_000249.4:p.S477A

Associated Papers

Key role of phosphorylation sites in ATPase domain and Linker region of MLH1 for DNA binding and functionality of MutLα.

Firnau MB et al.

Scientific Reports, 2023

High Expression of Casein Kinase 2 Alpha Is Responsible for Enhanced Phosphorylation of DNA Mismatch Repair Protein MLH1 and Increased Tumor Mutation Rates in Colorectal Cancer.

Ulreich K et al.

Cancers, 2022

DNA mismatch repair activity of MutLα is regulated by CK2-dependent phosphorylation of MLH1 (S477).

Weßbecher IM et al.

Molecular Carcinogenesis, 2018

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."