Associated Papers
Amphipathic N-terminal helices drive MLKL-mediated necroptosis through an antimicrobial peptide-like mechanism across evolution.
Tian X et al.
Developmental and Comparative Immunology, 2026
Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization.
Meng Y et al.
Nature Communications, 2023
The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling.
Zhang Y et al.
Cell Death & Disease, 2021
A plug release mechanism for membrane permeation by MLKL.
Su L et al.
Structure (london, England : 1993), 2014
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