Associated Papers
Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex.
Sun Y et al.
Nature Communications, 2025
40691140 (PubMed )
Supplement: 41467_2025_61939_MOESM5_ESM.pdf
Computational studies on the functional and structural impact of pathogenic mutations in enzymes.
Dissanayake UC et al.
Protein Science : a Publication of the Protein Society, 2025
Fifty years of the mitochondrial pyruvate carrier: New insights into its structure, function, and inhibition.
Tavoulari S et al.
Acta Physiologica (oxford, England), 2023
MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy.
Pujol C et al.
Brain : a Journal of Neurology, 2023
Ketogenic Diet Treatment of Defects in the Mitochondrial Malate Aspartate Shuttle and Pyruvate Carrier.
Bölsterli BK et al.
Nutrients, 2022
Identification and characterization of novel MPC1 gene variants causing mitochondrial pyruvate carrier deficiency.
Jiang H et al.
Journal of Inherited Metabolic Disease, 2022
Structural Insights into the Human Mitochondrial Pyruvate Carrier Complexes.
Xu L et al.
Journal of Chemical Information and Modeling, 2021
Sequence Features of Mitochondrial Transporter Protein Families.
Gyimesi G et al.
Biomolecules, 2020
Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity.
Nemani N et al.
Science Signaling, 2020
Two human patient mitochondrial pyruvate carrier mutations reveal distinct molecular mechanisms of dysfunction.
Oonthonpan L et al.
Jci Insight, 2019
Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses.
Li X et al.
Oncotarget, 2016
Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.
Yang C et al.
Molecular Cell, 2014
Regulation of pyruvate metabolism and human disease.
Gray LR et al.
Cellular and Molecular Life Sciences : Cmls, 2014
A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.
Bricker DK et al.
Science (new York, N.y.), 2012
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