Varaico: Literature-Extracted Genetic Variants

Gene:MPL
Variant:p.Y591N
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MPL

NM_005373.3:p.Y591N

Associated Papers

Non-MPL-W515K/L mutations in myeloproliferative neoplasms: Insights from two case reports and a review of the literature.

Tønne Nesse AS et al.

Expert Review of Hematology, 2025

Broad Next-Generation Integrated Sequencing of Myelofibrosis Identifies Disease-Specific and Age-Related Genomic Alterations.

Kandarpa M et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

38386293 (PubMed )
Supplement: ccr-23-0372_supplemental_table_2_suppst2.xlsx › Suppl._Table_2

Clinical laboratory characteristics and gene mutation spectrum of Ph-negative MPN patients with atypical variants of JAK2, MPL, or CALR.

Wang Z et al.

Cancer Medicine, 2024

Identification of putative noncanonical driver mutations in patients with essential thrombocythemia.

Arai A et al.

European Journal of Haematology, 2023

Concurrent Mutations in SF3B1 and PHF6 in Myeloid Neoplasms.

Zuo Z et al.

Biology, 2022

36671709 (PubMed )
Supplement: biology-12-00013-s001.zip › biology-2072813-supplementary.xlsx › Suppl_tbl_Vaf

Thrombocytosis in children and adolescents-classification, diagnostic approach, and clinical management.

Stockklausner C et al.

Annals of Hematology, 2021

STAT3 and STAT5B mutations have unique distribution in T-cell large granular lymphocyte proliferations and advanced myeloid neoplasms.

Qu S et al.

Leukemia & Lymphoma, 2021

Concomitant and noncanonical JAK2 and MPL mutations in JAK2V617F- and MPLW515 L-positive myelofibrosis.

Schulze S et al.

Genes, Chromosomes & Cancer, 2019

Philadelphia-Negative Myeloproliferative Neoplasms: Laboratory Workup in the Era of Next-Generation Sequencing.

Zuo Z et al.

Current Hematologic Malignancy Reports, 2019

Two activating mutations of MPL in triple-negative myeloproliferative neoplasms.

Xie J et al.

Cancer Medicine, 2019

MPL Y252H anMd PL F126fs mutations in essential thrombocythemia: Case series and review of literature.

Elsayed AG et al.

Hematology Reports, 2019

The Role of New Technologies in Myeloproliferative Neoplasms.

Palumbo GA et al.

Frontiers in Oncology, 2019

Mutations in myeloproliferative neoplasms - their significance and clinical use.

Schischlik F et al.

Expert Review of Hematology, 2017

Recommendations for molecular testing in classical Ph1-neg myeloproliferative disorders-A consensus project of the Italian Society of Hematology.

Guglielmelli P et al.

Leukemia Research, 2017

Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms.

Grinfeld J et al.

Haematologica, 2017

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients.

Cabagnols X et al.

Blood, 2016

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."