Associated Papers
Association of Mutations in the Melanocortin-2 Receptor Accessory Protein 2 Gene (MRAP2) and Obesity: A Systematic Review and Meta-Analysis.
Ji RL et al.
International Journal of Molecular Sciences, 2026
The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling.
Jamaluddin A et al.
Science Signaling, 2025
MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants.
Jamaluddin A et al.
Biorxiv : the Preprint Server for Biology, 2025
41040264 (PubMed )
Supplement: media-1.pdf
Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways.
Wyatt RA et al.
Human Molecular Genetics, 2025
The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling.
Jamaluddin A et al.
Biorxiv : the Preprint Server for Biology, 2024
Study of LEP, MRAP2 and POMC genes as potential causes of severe obesity in Brazilian patients.
da Fonseca ACP et al.
Eating and Weight Disorders : Ewd, 2021
Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiology.
Berruien NNA et al.
Gene, 2020
Pharmacological effect of human melanocortin-2 receptor accessory protein 2 variants on hypothalamic melanocortin receptors.
Liang J et al.
Endocrine, 2018
Decreased melanocortin-4 receptor function conferred by an infrequent variant at the human melanocortin receptor accessory protein 2 gene.
Schonnop L et al.
Obesity (silver Spring, Md.), 2016
Melanocortin receptor accessory proteins in adrenal disease and obesity.
Jackson DS et al.
Frontiers in Neuroscience, 2015
Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity.
Asai M et al.
Science (new York, N.y.), 2013
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