Associated Papers
Functional characterisation of obesity-associated MRAP2 variants on MC4R and GHSR signalling.
Rodríguez Rondón AV et al.
Human Molecular Genetics, 2026
MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants.
Jamaluddin A et al.
Cell Reports, 2026
Association of Mutations in the Melanocortin-2 Receptor Accessory Protein 2 Gene (MRAP2) and Obesity: A Systematic Review and Meta-Analysis.
Ji RL et al.
International Journal of Molecular Sciences, 2026
The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling.
Jamaluddin A et al.
Science Signaling, 2025
MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants.
Jamaluddin A et al.
Biorxiv : the Preprint Server for Biology, 2025
Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways.
Wyatt RA et al.
Human Molecular Genetics, 2025
The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling.
Jamaluddin A et al.
Biorxiv : the Preprint Server for Biology, 2024
Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiology.
Berruien NNA et al.
Gene, 2020
Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension.
Baron M et al.
Nature Medicine, 2019
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