Associated Papers
MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants.
Jamaluddin A et al.
Cell Reports, 2026
Association of Mutations in the Melanocortin-2 Receptor Accessory Protein 2 Gene (MRAP2) and Obesity: A Systematic Review and Meta-Analysis.
Ji RL et al.
International Journal of Molecular Sciences, 2026
The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling.
Jamaluddin A et al.
Science Signaling, 2025
MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants.
Jamaluddin A et al.
Biorxiv : the Preprint Server for Biology, 2025
Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways.
Wyatt RA et al.
Human Molecular Genetics, 2025
The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling.
Jamaluddin A et al.
Biorxiv : the Preprint Server for Biology, 2024
Medical semiology of patients with monogenic obesity: A systematic review.
Renard E et al.
Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, 2024
38956946 (PubMed )
Supplement: supplement_1.pdf
Study of LEP, MRAP2 and POMC genes as potential causes of severe obesity in Brazilian patients.
da Fonseca ACP et al.
Eating and Weight Disorders : Ewd, 2021
Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiology.
Berruien NNA et al.
Gene, 2020
Pharmacological effect of human melanocortin-2 receptor accessory protein 2 variants on hypothalamic melanocortin receptors.
Liang J et al.
Endocrine, 2018
Decreased melanocortin-4 receptor function conferred by an infrequent variant at the human melanocortin receptor accessory protein 2 gene.
Schonnop L et al.
Obesity (silver Spring, Md.), 2016
Melanocortin receptor accessory proteins in adrenal disease and obesity.
Jackson DS et al.
Frontiers in Neuroscience, 2015
Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity.
Asai M et al.
Science (new York, N.y.), 2013
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