Associated Papers
Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors.
Bonsor DA et al.
Nature Communications, 2026
Targeting the SHOC2-RAS interaction in RAS-mutant cancers.
Hauseman ZJ et al.
Nature, 2025
The small GTPase MRAS is a broken switch.
Bernal Astrain G et al.
Nature Communications, 2025
M-Ras distinct activation scenarios: A mechanistic outlook and targeting.
Xu L et al.
Computational and Structural Biotechnology Journal, 2025
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Holderfield M et al.
Nature, 2024
Structural insights into the role of SHOC2-MRAS-PP1C complex in RAF activation.
Bonsor DA et al.
The Febs Journal, 2023
Natural history of MRAS-related Noonan syndrome: Evidence of mild adult-onset left ventricular hypertrophy and neuropsychiatric features.
Priolo M et al.
American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 2023
Targeting KRASp.G12C Mutation in Advanced Non-Small Cell Lung Cancer: a New Era Has Begun.
Bungaro M et al.
Current Treatment Options in Oncology, 2022
Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
Bonsor DA et al.
Nature Structural & Molecular Biology, 2022
Structure of the MRAS-SHOC2-PP1C phosphatase complex.
Hauseman ZJ et al.
Nature, 2022
The RRAS2 pathogenic variant p.Q72L produces severe Noonan syndrome with hydrocephalus: A case report.
Weinstock NI et al.
American Journal of Medical Genetics. Part A, 2022
Diverse alterations associated with resistance to KRAS(G12C) inhibition.
Zhao Y et al.
Nature, 2021
Atypical, severe hypertrophic cardiomyopathy in a newborn presenting Noonan syndrome harboring a recurrent heterozygous MRAS variant.
Pires LVL et al.
American Journal of Medical Genetics. Part A, 2021
M-Ras is Muscle-Ras, Moderate-Ras, Mineral-Ras, Migration-Ras, and Many More-Ras.
Endo T
Experimental Cell Research, 2020
Severe Noonan syndrome phenotype associated with a germline Q71R MRAS variant: a recurrent substitution in RAS homologs in various cancers.
Suzuki H et al.
American Journal of Medical Genetics. Part A, 2019