Associated Papers
Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors.
Bonsor DA et al.
Nature Communications, 2026
The small GTPase MRAS is a broken switch.
Bernal Astrain G et al.
Nature Communications, 2025
Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
Bonsor DA et al.
Nature Structural & Molecular Biology, 2022
Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
Kwon JJ et al.
Nature, 2022
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Tran TH et al.
Nature Communications, 2021
SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics.
Boned Del Río I et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
MRAS: A Close but Understudied Member of the RAS Family.
Young LC et al.
Cold Spring Harbor Perspectives in Medicine, 2018
SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis.
Young LC et al.
Proceedings of the National Academy of Sciences of the United States of America, 2018
Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy.
Higgins EM et al.
Jci Insight, 2017
Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer.
Yasumoto M et al.
Cancer Medicine, 2017
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