Associated Papers
Pathogenic variation in human DNA damage repair genes was originated from the evolutionary process of modern humans.
Li J et al.
Genes & Diseases, 2026
Differential expression of a disease-associated MRE11 variant reveals distinct phenotypic outcomes.
DeFoer MB et al.
Human Molecular Genetics, 2025
Differential expression of a disease-associated MRE11 variant reveals distinct phenotypic outcomes.
DeFoer MB et al.
Biorxiv : the Preprint Server for Biology, 2025
Prevalence and clinical relavance of germline mutations in Chinese patients with pancreatic cancer.
Jiang Y et al.
Cell Communication and Signaling : Ccs, 2025
Risk of lymphoid malignancy associated with cancer predisposition genes.
Boddicker NJ et al.
Blood Cancer Journal, 2025
The MRE11-RAD50-NBS1 complex both starts and extends DNA end resection in mouse meiosis.
Kim S et al.
Biorxiv : the Preprint Server for Biology, 2024
Pathogenic variants in human DNA damage repair genes mostly arose in recent human history.
Zhao B et al.
Bmc Cancer, 2024
Germline Mutations in 32 Cancer Susceptibility Genes by Next-Generation Sequencing among Breast Cancer Patients.
Yang Y et al.
Oncology, 2024
Pathogenic variants in human DNA damage repair genes mostly arose after the latest human out-of-Africa migration.
He J et al.
Frontiers in Genetics, 2024
Clinical Utility of Optical Genome Mapping and 523-Gene Next Generation Sequencing Panel for Comprehensive Evaluation of Myeloid Cancers.
Sahajpal NS et al.
Cancers, 2023
An in-silico analysis to identify structural, functional and regulatory role of SNPs in hMRE11.
Tarapara B et al.
Journal of Biomolecular Structure & Dynamics, 2023
Cervical dystonia and no oculomotor apraxia as new manifestation of ataxia-telangiectasia-like disorder 1 - case report and review of the literature.
Bajek A et al.
Frontiers in Neurology, 2023
Germline Variants in 32 Cancer-Related Genes among 700 Chinese Breast Cancer Patients by Next-Generation Sequencing: A Clinic-Based, Observational Study.
Yang L et al.
International Journal of Molecular Sciences, 2022
Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations.
Qin Z et al.
Life Science Alliance, 2022
Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers.
Alblihy A et al.
Npj Breast Cancer, 2021
MRN Complex and Cancer Risk: Old Bottles, New Wine.
Elkholi IE et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2021
Investigating the causal role of MRE11A p.E506* in breast and ovarian cancer.
Elkholi IE et al.
Scientific Reports, 2021
Characteristics of Germline Non-BRCA Mutation Status of High-Risk Breast Cancer Patients in China and Correlation with High-Risk Factors and Multigene Testing Suggestions.
Su Y et al.
Frontiers in Genetics, 2021
Three new cases of ataxia-telangiectasia-like disorder: No impairment of the ATM pathway, but S-phase checkpoint defect.
Fiévet A et al.
Human Mutation, 2019
Ataxia-telangiectasia-like disorder in a family deficient for MRE11A, caused by a MRE11 variant.
Sedghi M et al.
Neurology. Genetics, 2018
Reversible mislocalization of a disease-associated MRE11 splice variant product.
Hartlerode AJ et al.
Scientific Reports, 2018
Association of DNA repair genes polymorphisms and mutations with increased risk of head and neck cancer: a review.
Dylawerska A et al.
Medical Oncology (northwood, London, England), 2017
Ataxia telangiectasia: more variation at clinical and cellular levels.
Taylor AM et al.
Clinical Genetics, 2015
Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study.
Damiola F et al.
Breast Cancer Research : Bcr, 2014
Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.
Regal JA et al.
Human Molecular Genetics, 2013
The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers.
Ziółkowska-Suchanek I et al.
Molecular Cancer, 2013
PhenoHM: human-mouse comparative phenome-genome server.
Sardana D et al.
Nucleic Acids Research, 2010
Discovering moderate-risk breast cancer susceptibility genes.
Hollestelle A et al.
Current Opinion in Genetics & Development, 2010
Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.
Bartkova J et al.
Molecular Oncology, 2008
A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation.
Du L et al.
Plos One, 2008
Molecular basis of ataxia telangiectasia and related diseases.
Ball LG et al.
Acta Pharmacologica Sinica, 2005
The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks.
Lavin MF
Dna Repair, 2004
MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder.
Delia D et al.
Human Molecular Genetics, 2004
Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis.
Taylor AM et al.
Dna Repair, 0