Associated Papers
MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice.
Lukaszewicz A et al.
Biorxiv : the Preprint Server for Biology, 2026
ZBP1 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in ovarian cancer.
Shi SN et al.
Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy, 2026
ATM priming and end resection-coupled phosphorylation of MRE11 is important for fork protection and replication restart.
Zhang H et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
PCAF promotes R-loop resolution via histone acetylation.
Lee SY et al.
Nucleic Acids Research, 2024
The MRE11-RAD50-NBS1 complex both starts and extends DNA end resection in mouse meiosis.
Kim S et al.
Biorxiv : the Preprint Server for Biology, 2024
MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.
Cho MG et al.
Nature, 2024
Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade.
Alblihy A et al.
International Journal of Molecular Sciences, 2023
Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
Rotheneder M et al.
Molecular Cell, 2023
Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis.
Lee J et al.
Nature Communications, 2022
Mapping the genetic landscape of DNA double-strand break repair.
Hussmann JA et al.
Cell, 2021
Analyzing the Opportunities to Target DNA Double-Strand Breaks Repair and Replicative Stress Responses to Improve Therapeutic Index of Colorectal Cancer.
Tomasini PP et al.
Cancers, 2021
The fragility of a structurally diverse duplication block triggers recurrent genomic amplification.
Suzuki R et al.
Nucleic Acids Research, 2021
A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and Humans.
Chansel-Da Cruz M et al.
Cell Reports, 2020
Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication.
Boeckemeier L et al.
Science Advances, 2020
UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks.
Akagawa R et al.
Iscience, 2020
MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts.
Chang EY et al.
Nature Communications, 2019
CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs.
Mohiuddin M et al.
Nucleic Acids Research, 2019
Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities.
Moiani D et al.
Methods in Enzymology, 2018
MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.
Spehalski E et al.
Cancer Research, 2017
Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.
Hoa NN et al.
Molecular Cell, 2016
Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks.
Chanut P et al.
Nature Communications, 2016
Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
Lee JH et al.
The Journal of Biological Chemistry, 2013
The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair.
Reis CC et al.
The Embo Journal, 2012
Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.
Limbo O et al.
Nucleic Acids Research, 2012
The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.
Yu Z et al.
Cell Research, 2012
Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.
Buis J et al.
Nature Structural & Molecular Biology, 2012
The MRE11 complex: starting from the ends.
Stracker TH et al.
Nature Reviews. Molecular Cell Biology, 2011
Double functions for the Mre11 complex during DNA double-strand break repair and replication.
Borde V et al.
The International Journal of Biochemistry & Cell Biology, 2009
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.
Deriano L et al.
Molecular Cell, 2009
Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation.
Buis J et al.
Cell, 2008
Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
Williams RS et al.
Cell, 2008
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography.
Thompson LH
Mutation Research, 0