Associated Papers
Risk of lymphoid malignancy associated with cancer predisposition genes.
Boddicker NJ et al.
Blood Cancer Journal, 2025
Prevalence of germline variants in Brazilian pancreatic carcinoma patients.
Rodrigues LM et al.
Scientific Reports, 2024
Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder.
Hartlerode AJ et al.
Human Molecular Genetics, 2024
An in-silico analysis to identify structural, functional and regulatory role of SNPs in hMRE11.
Tarapara B et al.
Journal of Biomolecular Structure & Dynamics, 2023
Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN Complex.
Otahalova B et al.
International Journal of Molecular Sciences, 2023
Cervical dystonia and no oculomotor apraxia as new manifestation of ataxia-telangiectasia-like disorder 1 - case report and review of the literature.
Bajek A et al.
Frontiers in Neurology, 2023
High efficiency and clinical relevance of exome sequencing in the daily practice of neurogenetics.
Thomas Q et al.
Journal of Medical Genetics, 2022
Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency.
Lee JH et al.
Molecular Cell, 2021
A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex.
Rahman S et al.
Cells, 2020
Three new cases of ataxia-telangiectasia-like disorder: No impairment of the ATM pathway, but S-phase checkpoint defect.
Fiévet A et al.
Human Mutation, 2019
Familial breast cancer and DNA repair genes: Insights into known and novel susceptibility genes from the GENESIS study, and implications for multigene panel testing.
Girard E et al.
International Journal of Cancer, 2019
Structure-function relationships of the Mre11 protein in the control of DNA end bridging and processing.
Marsella A et al.
Current Genetics, 2019
Ataxia-telangiectasia-like disorder in a family deficient for MRE11A, caused by a MRE11 variant.
Sedghi M et al.
Neurology. Genetics, 2018
Reversible mislocalization of a disease-associated MRE11 splice variant product.
Hartlerode AJ et al.
Scientific Reports, 2018
Germline Mutation Status, Pathological Complete Response, and Disease-Free Survival in Triple-Negative Breast Cancer: Secondary Analysis of the GeparSixto Randomized Clinical Trial.
Hahnen E et al.
Jama Oncology, 2017
MRE11 stability is regulated by CK2-dependent interaction with R2TP complex.
von Morgen P et al.
Oncogene, 2017
Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.
Regal JA et al.
Human Molecular Genetics, 2013
Next generation sequencing for molecular diagnosis of neurological disorders using ataxias as a model.
Németh AH et al.
Brain : a Journal of Neurology, 2013
Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.
Limbo O et al.
Nucleic Acids Research, 2012
Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Schiller CB et al.
Nature Structural & Molecular Biology, 2012
Mre11 modulates the fidelity of fusion between short telomeres in human cells.
Tankimanova M et al.
Nucleic Acids Research, 2012
Crystal structure of human Mre11: understanding tumorigenic mutations.
Park YB et al.
Structure (london, England : 1993), 2011
Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks.
Williams GJ et al.
Dna Repair, 2010
Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.
Bartkova J et al.
Molecular Oncology, 2008
Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
Williams RS et al.
Cell, 2008
A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner.
Wen Q et al.
Molecular Biology of the Cell, 2008
Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder.
Fernet M et al.
Human Molecular Genetics, 2005
The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks.
Lavin MF
Dna Repair, 2004
MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder.
Delia D et al.
Human Molecular Genetics, 2004
Delineation of the role of the Mre11 complex in class switch recombination.
Lähdesmäki A et al.
The Journal of Biological Chemistry, 2004
Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.
Lee JH et al.
The Journal of Biological Chemistry, 2003
The Mre11 complex: at the crossroads of dna repair and checkpoint signalling.
D'Amours D et al.
Nature Reviews. Molecular Cell Biology, 2002
Ataxia without telangiectasia revisited: update on genetic findings in two brothers with an ataxia-telangiectasia-like disorder.
Klein C et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2001
Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase.
Hopfner KP et al.
Cell, 2001
[Ataxia telangiectasia, immunity disorders, terminal lymphosarcomatosis in 2 brothers].
Castaigne P et al.
La Presse Medicale, 1969
The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together.
Stracker TH et al.
Dna Repair, 0
Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis.
Taylor AM et al.
Dna Repair, 0