Associated Papers
Classification of MSH6 Variants of Uncertain Significance Using Functional Assays.
Frederiksen JH et al.
International Journal of Molecular Sciences, 2021
Mispair-bound human MutS-MutL complex triggers DNA incisions and activates mismatch repair.
Ortega J et al.
Cell Research, 2021
Massively parallel functional testing of MSH2 missense variants conferring Lynch syndrome risk.
Jia X et al.
American Journal of Human Genetics, 2021
Functional interrogation of Lynch syndrome-associated MSH2 missense variants via CRISPR-Cas9 gene editing in human embryonic stem cells.
Rath A et al.
Human Mutation, 2019
Methylation Tolerance-Based Functional Assay to Assess Variants of Unknown Significance in the MLH1 and MSH2 Genes and Identify Patients With Lynch Syndrome.
Bouvet D et al.
Gastroenterology, 2019
Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing.
Hayashida G et al.
Experimental Cell Research, 2019
Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants.
Houlleberghs H et al.
Proceedings of the National Academy of Sciences of the United States of America, 2016
Mutations in the nucleotide binding and hydrolysis domains of Helicobacter pylori MutS2 lead to altered biochemical activities and inactivation of its in vivo function.
Damke PP et al.
Bmc Microbiology, 2016
Mouse models of DNA mismatch repair in cancer research.
Lee K et al.
Dna Repair, 2016
Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases.
Zanotti KJ et al.
Dna Repair, 2016
The UvrD303 hyper-helicase exhibits increased processivity.
Meiners MJ et al.
The Journal of Biological Chemistry, 2014
The dual nature of mismatch repair as antimutator and mutator: for better or for worse.
Bak ST et al.
Frontiers in Genetics, 2014
Mutation rates, spectra, and genome-wide distribution of spontaneous mutations in mismatch repair deficient yeast.
Lang GI et al.
G3 (bethesda, Md.), 2013
Biochemical analysis of the human mismatch repair proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D).
Geng H et al.
The Journal of Biological Chemistry, 2012
Mismatch-mediated error prone repair at the immunoglobulin genes.
Chahwan R et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2011
Conformational trapping of mismatch recognition complex MSH2/MSH3 on repair-resistant DNA loops.
Lang WH et al.
Proceedings of the National Academy of Sciences of the United States of America, 2011
Mismatch and base excision repair proficiency in murine embryonic stem cells.
Tichy ED et al.
Dna Repair, 2011
Verification of the three-step model in assessing the pathogenicity of mismatch repair gene variants.
Kansikas M et al.
Human Mutation, 2011
An MLH1 mutation links BACH1/FANCJ to colon cancer, signaling, and insight toward directed therapy.
Xie J et al.
Cancer Prevention Research (philadelphia, Pa.), 2010
Making sense of missense in Lynch syndrome: the clinical perspective.
Lynch HT et al.
Cancer Prevention Research (philadelphia, Pa.), 2010
Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair.
Cantor SB et al.
Environmental and Molecular Mutagenesis, 2010
An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.
Kucherlapati MH et al.
Gastroenterology, 2010
Preservation of genomic integrity in mouse embryonic stem cells.
Stambrook PJ et al.
Advances in Experimental Medicine and Biology, 2010
The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.
Frieder D et al.
Molecular and Cellular Biology, 2009
MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.
Tomé S et al.
Plos Genetics, 2009
Mechanisms of pathogenicity in human MSH2 missense mutants.
Ollila S et al.
Human Mutation, 2008
Functional analysis of HNPCC-related missense mutations in MSH2.
Lützen A et al.
Mutation Research, 2008
The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells.
Seifert M et al.
The Journal of Investigative Dermatology, 2008
Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues.
Bhattacharya P et al.
European Journal of Immunology, 2008
Signalling cell cycle arrest and cell death through the MMR System.
O'Brien V et al.
Carcinogenesis, 2006
Mutations in the nucleotide-binding domain of MutS homologs uncouple cell death from cell survival.
Drotschmann K et al.
Dna Repair, 2004
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis.
Lin DP et al.
Cancer Research, 2004
DNA mismatch repair: molecular mechanism, cancer, and ageing.
Hsieh P et al.
Mechanisms of Ageing and Development, 0
Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity.
Iwaizumi M et al.
Mutation Research, 0