Varaico: Literature-Extracted Genetic Variants

Gene:MSH6
Variant:p.S459F
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MSH6

NM_000179.3:p.S459F

Associated Papers

Advances in immunotherapy for colorectal cancer: overcoming resistance in mismatch repair-proficient tumors.

Keivany MR et al.

Cancer Cell International, 2026

Morphomolecular Correlation and Clinicopathologic Analysis in Endometrial Carcinoma.

Bülbül G et al.

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists, 2024

Morules and β-catenin predict POLE mutation status in endometrial cancer: A pathway to more cost-effective diagnostic procedures.

Fan R et al.

American Journal of Clinical Pathology, 2024

Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variants.

Selves J et al.

Life Science Alliance, 2024

The game-changing impact of POLE mutations in oncology-a review from a gynecologic oncology perspective.

Kögl J et al.

Frontiers in Oncology, 2024

Replication DNA polymerases, genome instability and cancer therapies.

Strauss JD et al.

Nar Cancer, 2023

Molecular Profiling of Endometrial Cancer: An Exploratory Study in Aotearoa, New Zealand.

Henry CE et al.

Cancers, 2021

Endometrial cancer with a POLE mutation progresses frequently through the type I pathway despite its high-grade endometrioid morphology: a cohort study at a single institution in Japan.

Monsur M et al.

Medical Molecular Morphology, 2021

Genomic Alterations of NTRK, POLE, ERBB2, and Microsatellite Instability Status in Chinese Patients with Colorectal Cancer.

Guo Y et al.

The Oncologist, 2020

Polymerase epsilon mutations and concomitant β2-microglobulin mutations in cancer.

Voutsadakis IA

Gene, 2018

Polymerase proofreading domain mutations: New opportunities for immunotherapy in hypermutated colorectal cancer beyond MMR deficiency.

Bourdais R et al.

Critical Reviews in Oncology/hematology, 2017

Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis.

Erson-Omay EZ et al.

Neuro-oncology, 2015

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."