Associated Papers
Evidence for interaction of 5,10-methylenetetrahydrofolate reductase (MTHFR) with methylenetetrahydrofolate dehydrogenase (MTHFD1) and general control nonderepressible 1 (GCN1).
Büchler LR et al.
Biochimie, 2025
Structural basis of S-adenosylmethionine-dependent allosteric transition from active to inactive states in methylenetetrahydrofolate reductase.
Yamada K et al.
Nature Communications, 2024
38886362 (PubMed )
Supplement: 41467_2024_49327_MOESM1_ESM.pdf
The Implication of a Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Homocysteine Metabolism and Related Civilisation Diseases.
Zarembska E et al.
International Journal of Molecular Sciences, 2023
Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase.
Zheng Y et al.
Scientific Reports, 2019
Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.
Froese DS et al.
Nature Communications, 2018
Polo-like kinase 1 (PLK1)-dependent phosphorylation of methylenetetrahydrofolate reductase (MTHFR) regulates replication via histone methylation.
Li X et al.
Cell Cycle (georgetown, Tex.), 2017
Mutation Update and Review of Severe Methylenetetrahydrofolate Reductase Deficiency.
Froese DS et al.
Human Mutation, 2016
The prevalence of folate-remedial MTHFR enzyme variants in humans.
Marini NJ et al.
Proceedings of the National Academy of Sciences of the United States of America, 2008
Regulation of human methylenetetrahydrofolate reductase by phosphorylation.
Yamada K et al.
Proceedings of the National Academy of Sciences of the United States of America, 2005
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