Associated Papers
mTOR Variants Activation Discovers PI3K-like Cryptic Pocket, Expanding Allosteric, Mutant-Selective Inhibitor Designs.
Liu Y et al.
Journal of Chemical Information and Modeling, 2025
mTOR variants activation discovers PI3K-like cryptic pocket, expanding allosteric, mutant-selective inhibitor designs.
Liu Y et al.
Biorxiv : the Preprint Server for Biology, 2024
Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery.
Hsieh HJ et al.
Nature Communications, 2018
Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass.
Alejandro EU et al.
Diabetes, 2017
MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy.
Ma X et al.
Autophagy, 2017
ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).
Carriere A et al.
The Journal of Biological Chemistry, 2011
Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.
Foster KG et al.
The Journal of Biological Chemistry, 2010
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.
Risson V et al.
The Journal of Cell Biology, 2009
A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice.
Shor B et al.
Bmc Immunology, 2009
Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway.
Shegogue D et al.
The Journal of Biological Chemistry, 2004
Myogenic differentiation is dependent on both the kinase function and the N-terminal sequence of mammalian target of rapamycin.
Shu L et al.
The Journal of Biological Chemistry, 2002
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