Varaico: Literature-Extracted Genetic Variants

Gene:MTRR
Variant:p.I22M
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MTRR

NM_002454.3:p.I22M

Associated Papers

The molecular puzzle of recurrent implantation failure: integrating genetic, epigenetic, and immune mechanisms for precision reproductive medicine.

Abuhassan Q et al.

Journal of Assisted Reproduction and Genetics, 2026

Association of CYP2C19 Single Nucleotide Polymorphism With Hemorrhagic Cystitis After Pediatric Allogeneic Hematopoietic Stem Cell Transplantation.

Zhang W et al.

Clinical Transplantation, 2026

MTHFR and MTRR Polymorphisms Predict Sex-Dependent Psychotic Symptom Improvements, Not Metabolic Changes.

Nadalin S et al.

International Journal of Molecular Sciences, 2026

Distribution of Thrombophilia-Related Genetic Polymorphisms in Women with Reproductive Disorders.

Kurmanova A et al.

Biomedicines, 2026

Molecular and multimodal biomarkers in Moyamoya disease: from pathogenic mechanisms to clinical translation.

Li J et al.

European Journal of Medical Research, 2026

Evaluating the Impact of Folate on Male Infertility Using Mendelian Randomization: A Comprehensive Analysis.

Wang W et al.

The World Journal of Men's Health, 2026

Association analysis of MTHFR (C677T, A1298C) and MTRR (A66G) gene polymorphisms on susceptibility to gestational diabetes mellitus in Chinese pregnant women.

Han W et al.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 2025

Relationship between MTHFR, MTRR gene polymorphisms and H-type hypertension: a systematic review and meta-analysis.

Gao L et al.

Annals of Human Biology, 2025

Genetic polymorphisms in folate metabolism and their association with recurrent spontaneous abortion.

Wu AN et al.

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2025

Methylenetetrahydrofolate Reductase and Methionine Synthase Reductase Polymorphisms: Genetic Predictors of Congenital Heart Disease Subtypes.

Tripathi S et al.

Cureus, 2025

Association of folate metabolism gene polymorphisms with autism susceptibility and symptom severity in the Chinese population.

Zhang CY et al.

World Journal of Psychiatry, 2025

Association Between Folate Metabolism Risk, Collateral Circulation, and Hemorrhagic Risk in Moyamoya Disease.

Li J et al.

Translational Stroke Research, 2025

Genotype Combinations and Genetic Risk Score Analyses of MTHFR, MTRR, and MTR Polymorphisms in Hypothyroidism Susceptibility: A Case-Control Study.

Tabakoglu NT et al.

Current Issues in Molecular Biology, 2025

Association Between MTRR 66 A/G and MTR 2756 A/G Polymorphisms and Response to Methotrexate in Rheumatoid Arthritis. A Meta-analysis.

Lee YH et al.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases, 2025

Dietary and Circulating Vitamins, Polymorphisms of Vitamin Metabolism Genes, and the Risk of Gastrointestinal Cancers: A Systematic Review and Meta-Analysis.

Wang XL et al.

Clinical and Translational Gastroenterology, 2025

Unusual Comorbid Condition in a Child with Severe Factor XI Deficiency: Spina Bifida

Kahraman A et al.

Turkish Journal of Haematology : Official Journal of Turkish Society of Haematology, 2025

GeneRiskCalc: a web-based tool for genetic risk association analysis in case-control studies.

Sudershan A et al.

Bmc Bioinformatics, 2025

40830932 (PubMed )
Supplement: 12859_2025_6207_MOESM2_ESM.docx

Synergistic Effects of MTHFR, MTRR, and MTR Gene Variants on Serum Folate Levels and Cognitive Function in Chinese Preschoolers: A Cross-Sectional Study.

Ou L et al.

Nutrients, 2025

Is there a causal link between folate status and schizophrenia? Evidence from genetic association studies.

Yoo S et al.

Nutritional Neuroscience, 2025

Molecular Determinants of the Human Retinal Pigment Epithelium Cell Fate and Potential Pharmacogenomic Targets for Precision Medicine.

Zibetti C

International Journal of Molecular Sciences, 2025

40565279 (PubMed )
Supplement: ijms-26-05817-s001.zip › Table_S1_NGS_qc_and_WES_April2025_2_.xlsx › D2_hiPSCsvsPBMC_SNPs_InDels

Relationship of Choline Intake with Biomarkers of Liver Health by Genotype-A Cross-Sectional Analysis.

Wallace TC et al.

The Journal of Nutrition, 2025

Safety and Efficacy of High-Dose Folinic Acid in Children with Autism: The Impact of Folate Metabolism Gene Polymorphisms.

Zhang C et al.

Nutrients, 2025

Contribution of Methylenetetrahydrofolate Reductase Genotypes to Brain Tumor Risk Determination in Taiwan.

Chen CH et al.

Anticancer Research, 2025

Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension.

Siddiqi SM et al.

The Journal of Nutrition, 2025

Reassessment of MTRR rs1801394 Polymorphism and Neural Tube Defects Risk.

Muruganantham JK et al.

Maternal-fetal Medicine (wolters Kluwer Health, Inc.), 2025

Functional Evaluation of Neural Tube Defect-Related Missense Mutations Using In Silico Methods.

Biterge Sut B

Birth Defects Research, 2025

Interrelationships among MTHFR gene polymorphisms, MTRR gene polymorphisms, and HBV gene BCP 1762/1764 mutations with disease progression in Chronic hepatitis B virus infection patients.

Shunhua Q et al.

Nucleosides, Nucleotides & Nucleic Acids, 2025

[The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children].

Strozenko LA et al.

Zhurnal Nevrologii I Psikhiatrii Imeni S.s. Korsakova, 2025

Hyperhomocysteinemia in Takayasu arteritis-genetically defined or burden of the proinflammatory state?

Zarur EB et al.

Frontiers in Immunology, 2025

Rare and novel variant load threshold for KIF7, GJA1 and PDE1C genes elevates the risk of severity of congenital heart defects in Down syndrome.

Ganguly A et al.

Plos One, 2025

Impact of cyclosporine A-related single nucleotide polymorphisms on post-transplant outcomes in pediatric hematologic malignancy patients undergoing allogeneic hematopoietic stem cell transplantation.

Ji Q et al.

Frontiers in Immunology, 2025

Association of folate metabolism-related enzymes (MTHFR, MYD88, and TP53) and their single nucleotide polymorphisms with breast cancer susceptibility in women from Southwest China: a Bayesian network approach.

Li X et al.

Frontiers in Oncology, 2025

Severe hematologic toxicity after low-dose methotrexate in ectopic pregnancy: role of MTHFR polymorphism and drug interaction - a case report and literature review.

Huang X et al.

Frontiers in Pharmacology, 2025

MTHFR 677C/T gene polymorphism and dietary habits: effects on trace element levels, amino acids, and biochemical parameters.

Orct T et al.

Frontiers in Nutrition, 2025

Association between CBS gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region and coronary artery disease: a meta-analysis.

Zhu Z et al.

Clinical and Experimental Hypertension (new York, N.y. : 1993), 2024

Global DNA Methylation Levels Viz-a-Viz Genetic and Biochemical Variations in One Carbon Metabolic Pathway: An Exploratory Study from North India.

Chaudhary V et al.

Biochemical Genetics, 2024

Dietary folic acid intake, 13 genetic variants and other factors with red blood cell folate concentration in pregnancy-preparing population.

He W et al.

European Journal of Nutrition, 2024

The association between methionine synthase reductase c.66A>G variant and the risk of recurrent pregnancy loss: A systematic review and meta-analysis.

Zhou J et al.

Journal of Gynecology Obstetrics and Human Reproduction, 2024

Folate and cobalamin status, indicators, modulators, interactions, and reference ranges from early pregnancy until birth: the Reus-Tarragona birth cohort study.

Santos-Calderón LA et al.

The American Journal of Clinical Nutrition, 2024

MTHFR C677T、MTHFR A1298C、MTRR A66G and MTR A2756G polymorphisms and male infertility risk: a systematic review and meta-analysis.

Li F et al.

Reproductive Biology and Endocrinology : Rb&e, 2024

Do aluminum, boron, arsenic, cadmium, lipoperoxidation, and genetic polymorphism determine male fertility?

Baszyński J et al.

Ecotoxicology and Environmental Safety, 2024

Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms and five related serum molecular levels in 2587 patients: Associated differentially with adverse pregnancy.

Feng Z et al.

Molecular Biology Reports, 2024

Association of MTR and MTRR polymorphisms with recurrent pregnancy loss: a case control study.

Shaker MM et al.

Molecular Biology Reports, 2024

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."