Associated Papers
MYBPC3 N-terminal missense mutations linked to hypertrophic cardiomyopathy strengthen actin binding and enhance residue mobility.
Kanassatega RS et al.
The Journal of Biological Chemistry, 2025
Myosin-binding protein C slows cardiac myofibril relaxation kinetics.
Dvornikov AV et al.
The Journal of Physiology, 2025
The L348P point mutation in cardiac myosin binding protein-C alters transient responses to stretch, slows cardiac relaxation, and is embryonic lethal in homozygous CRISPR gene-edited mice.
Sadler RL et al.
Journal of Molecular and Cellular Cardiology, 2025
Disparate Molecular Properties of Two Hypertrophic Cardiomyopathy-Associated cMyBP-C Mutants Reveal Distinct Pathogenic Mechanisms Beyond Haploinsufficiency.
Thanassoulas A et al.
Biomedicines, 2025
Mavacamten Inhibits the Effect of the N-Terminal Fragment of Cardiac Myosin-Binding Protein C with the L352P Mutation on the Actin-Myosin Interaction at Low Calcium Concentrations.
Kochurova AM et al.
Biochemistry. Biokhimiia, 2025
The N-Terminal Mutations of cMyBP-C Affect Calcium Regulation, Kinetics, and Force of Muscle Contraction.
Nabiev SR et al.
International Journal of Molecular Sciences, 2024
The D75N and P161S Mutations in the C0-C2 Fragment of cMyBP-C Associated with Hypertrophic Cardiomyopathy Disturb the Thin Filament Activation, Nucleotide Exchange in Myosin, and Actin-Myosin Interaction.
Kochurova AM et al.
International Journal of Molecular Sciences, 2024
Cardiac myosin-binding protein C N-terminal interactions with myosin and actin filaments: Opposite effects of phosphorylation and M-domain mutations.
Wong FL et al.
Journal of Molecular and Cellular Cardiology, 2024
Cryo-Electron Microscopy Reveals Cardiac Myosin Binding Protein-C M-Domain Interactions with the Thin Filament.
Risi CM et al.
Journal of Molecular Biology, 2022
A high-throughput fluorescence lifetime-based assay to detect binding of myosin-binding protein C to F-actin.
Bunch TA et al.
The Journal of General Physiology, 2021
Point mutations in the tri-helix bundle of the M-domain of cardiac myosin binding protein-C influence systolic duration and delay cardiac relaxation.
van Dijk SJ et al.
Journal of Molecular and Cellular Cardiology, 2018
The cMyBP-C HCM variant L348P enhances thin filament activation through an increased shift in tropomyosin position.
Mun JY et al.
Journal of Molecular and Cellular Cardiology, 2016
The motif of human cardiac myosin-binding protein C is required for its Ca2+-dependent interaction with calmodulin.
Lu Y et al.
The Journal of Biological Chemistry, 2012
Cardiac myosin binding protein C: its role in physiology and disease.
Flashman E et al.
Circulation Research, 2004
Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy.
Richard P et al.
Circulation, 2003