Varaico: Literature-Extracted Genetic Variants

Gene:NCF1
Variant:p.W193R
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NCF1

NM_000265.7:p.W193R

Associated Papers

p47phox: A Central Regulator of NADPH Oxidase Function and a Promising Therapeutic Target in Redox-Related Diseases.

Gamble ME et al.

Cells, 2025

p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation.

Li XJ et al.

The Journal of Biological Chemistry, 2010

Tripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox, p67phox, and Rac1 elicit activator-independent superoxide production by phagocyte membranes: an essential role for anionic membrane phospholipids.

Berdichevsky Y et al.

The Journal of Biological Chemistry, 2007

Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent alpha-helix of p22phox.

Nobuhisa I et al.

The Biochemical Journal, 2006

Specificity of p47phox SH3 domain interactions in NADPH oxidase assembly and activation.

de Mendez I et al.

Molecular and Cellular Biology, 1997

Assembly and activation of the phagocyte NADPH oxidase. Specific interaction of the N-terminal Src homology 3 domain of p47phox with p22phox is required for activation of the NADPH oxidase.

Sumimoto H et al.

The Journal of Biological Chemistry, 1996

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."