Varaico: Literature-Extracted Genetic Variants

Gene:NCSTN
Variant:p.E333A
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NCSTN

NM_015331.3:p.E333A

Associated Papers

Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies.

Zhang X et al.

Proceedings of the National Academy of Sciences of the United States of America, 2012

Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.

Pamrén A et al.

The Journal of Biological Chemistry, 2011

Glu-333 of nicastrin directly participates in gamma-secretase activity.

Dries DR et al.

The Journal of Biological Chemistry, 2009

Nicastrin functions as a gamma-secretase-substrate receptor.

Shah S et al.

Cell, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."