Associated Papers
p53-dependent control of cell death by nicastrin: lack of requirement for presenilin-dependent gamma-secretase complex.
Pardossi-Piquard R et al.
Journal of Neurochemistry, 2009
A novel alternative splice variant of nicastrin and its implication in Alzheimer disease.
Mitsuda N et al.
Life Sciences, 2006
Nicastrin functions as a gamma-secretase-substrate receptor.
Shah S et al.
Cell, 2005
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
Shirotani K et al.
Journal of Neurochemistry, 2004
The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex.
Morais VA et al.
The Journal of Biological Chemistry, 2003
Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.
Li J et al.
The Journal of Biological Chemistry, 2003
Overexpression of nicastrin increases Abeta production.
Murphy MP et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2003
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins.
Yang DS et al.
The Journal of Biological Chemistry, 2002
Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.
Hu Y et al.
Developmental Cell, 2002
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