Varaico: Literature-Extracted Genetic Variants

Gene:NEDD8
Variant:p.K22R
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NEDD8

NM_006156.3:p.K22R

Associated Papers

A lysine-to-arginine mutation on NEDD8 markedly reduces the activity of cullin RING E3 ligase through the impairment of neddylation cascades.

Sui Y et al.

Biochemical and Biophysical Research Communications, 2015

The essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in Schizosaccharomyces pombe.

Girdwood D et al.

Plos One, 2011

21655279 (PubMed )
Supplement: pone.0020089.s001.xls › Sheet1
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."