Associated Papers
Functional annotation of the Hippo pathway somatic mutations in human cancers.
Han H et al.
Nature Communications, 2024
MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features.
Eaton CD et al.
Nature Communications, 2024
Missense variant interaction scanning reveals a critical role of the FERM domain for tumor suppressor protein NF2 conformation and function.
Moesslacher CS et al.
Life Science Alliance, 2023
MerlinS13 phosphorylation controls meningioma Wnt signaling and magnetic resonance imaging features.
Eaton C et al.
Research Square, 2023
Re-evaluation of missense variant classifications in NF2.
Sadler KV et al.
Human Mutation, 2022
Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity.
Meng F et al.
Molecular Cell, 2021
Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF complex.
Roehrig AE et al.
Plos One, 2021
The paradox of cancer genes in non-malignant conditions: implications for precision medicine.
Adashek JJ et al.
Genome Medicine, 2020
Frequency of the Loss of Heterozygosity of the NF2 Gene in Sporadic Spinal Schwannomas.
DE Carvalho RM et al.
Anticancer Research, 2018
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus.
Li W et al.
Cancer Cell, 2014
Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2.
Yin F et al.
Cell, 2013
Genetic and epigenetic alterations of the NF2 gene in sporadic vestibular schwannomas.
Lee JD et al.
Plos One, 2012
Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression.
Cooper J et al.
Science Signaling, 2011
Missense mutations in the NF2 gene result in the quantitative loss of merlin protein and minimally affect protein intrinsic function.
Yang C et al.
Proceedings of the National Academy of Sciences of the United States of America, 2011
Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findings.
Ahronowitz I et al.
Human Mutation, 2007
Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling.
Scoles DR et al.
Human Molecular Genetics, 2002
The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene product.
Kang BS et al.
Acta Crystallographica. Section D, Biological Crystallography, 2002
Effects of Nf2 missense mutations on schwannomin interactions.
Scoles DR et al.
Biochemical and Biophysical Research Communications, 2002
The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate.
Scoles DR et al.
Human Molecular Genetics, 2000
A missense mutation in the NF2 gene results in moderate and mild clinical phenotypes of neurofibromatosis type 2.
Kluwe L et al.
Human Genetics, 1996