Associated Papers
Merlin tumor suppressor function is regulated by PIP2-mediated dimerization.
Hennigan RF et al.
Plos One, 2023
Mosaicism in Tumor Suppressor Gene Syndromes: Prevalence, Diagnostic Strategies, and Transmission Risk.
Chen JL et al.
Annual Review of Genomics and Human Genetics, 2022
36044908 (PubMed )
Supplement: gg23-giannikou_suptable1.xlsx › NF2
Re-evaluation of missense variant classifications in NF2.
Sadler KV et al.
Human Mutation, 2022
Proximity biotinylation identifies a set of conformation-specific interactions between Merlin and cell junction proteins.
Hennigan RF et al.
Science Signaling, 2019
Frequency of the Loss of Heterozygosity of the NF2 Gene in Sporadic Spinal Schwannomas.
DE Carvalho RM et al.
Anticancer Research, 2018
FERM domain phosphoinositide binding targets merlin to the membrane and is essential for its growth-suppressive function.
Mani T et al.
Molecular and Cellular Biology, 2011
The merlin interacting proteins reveal multiple targets for NF2 therapy.
Scoles DR
Biochimica Et Biophysica Acta, 2008
Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain.
Li Q et al.
Journal of Molecular Biology, 2007
Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findings.
Ahronowitz I et al.
Human Mutation, 2007
Effects of Nf2 missense mutations on schwannomin interactions.
Scoles DR et al.
Biochemical and Biophysical Research Communications, 2002
Binding of the merlin-I product of the neurofibromatosis type 2 tumour suppressor gene to a novel site in beta-fodrin is regulated by association between merlin domains.
Neill GW et al.
The Biochemical Journal, 2001
The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate.
Scoles DR et al.
Human Molecular Genetics, 2000
Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin.
Scoles DR et al.
Nature Genetics, 1998
A missense mutation in the NF2 gene results in moderate and mild clinical phenotypes of neurofibromatosis type 2.
Kluwe L et al.
Human Genetics, 1996
Exon scanning for mutation of the NF2 gene in schwannomas.
Jacoby LB et al.
Human Molecular Genetics, 1994
Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types.
Bianchi AB et al.
Nature Genetics, 1994
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