Associated Papers
An animal model of NLRC4-associated autoinflammation and infantile enterocolitis reveals novel therapeutic strategies.
Wang Y et al.
Cellular & Molecular Immunology, 2025
Dysregulation of inflammasomes in autoinflammatory diseases.
Hou C et al.
Joint Bone Spine, 2025
NLRC4, inflammation and colorectal cancer (Review).
Tong G et al.
International Journal of Oncology, 2024
Human NLRC4 expression promotes cancer survival and associates with type I interferon signaling and immune infiltration.
Domblides C et al.
The Journal of Clinical Investigation, 2024
Genetics of Primary Hemophagocytic Lymphohistiocytosis.
Karageorgos S et al.
Advances in Experimental Medicine and Biology, 2024
Early-onset recurrent panniculitis as a phenotype of NLRC4-associated autoinflammatory syndrome: Characterization of pathogenicity of the p.Ser445Pro NLRC4 variant.
Gil-Lianes J et al.
The Australasian Journal of Dermatology, 2023
The autoinflammation-associated NLRC4V341A mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice.
Eeckhout E et al.
Frontiers in Immunology, 2023
Pathogenic insights from genetic causes of autoinflammatory inflammasomopathies and interferonopathies.
Lin B et al.
The Journal of Allergy and Clinical Immunology, 2022
Molecular diagnosis of childhood immune dysregulation, polyendocrinopathy, and enteropathy, and implications for clinical management.
Baxter SK et al.
The Journal of Allergy and Clinical Immunology, 2022
NLRC4 GOF Mutations, a Challenging Diagnosis from Neonatal Age to Adulthood.
Bardet J et al.
Journal of Clinical Medicine, 2021
Coronavirus Disease 2019 in a Patient With a Systemic Autoinflammatory Syndrome due to an NLRC4 Inflammasomopathy.
Duncan-Lowey JK et al.
Open Forum Infectious Diseases, 2021
A Novel Mutation in the NBD Domain of NLRC4 Causes Mild Autoinflammation With Recurrent Urticaria.
Wang L et al.
Frontiers in Immunology, 2021
ATP-Binding and Hydrolysis in Inflammasome Activation.
Sandall CF et al.
Molecules (basel, Switzerland), 2020
NLRC4 biology in immunity and inflammation.
Andrade WA et al.
Journal of Leukocyte Biology, 2020
Human Autoinflammatory Diseases Mediated by NLRP3-, Pyrin-, NLRP1-, and NLRC4-Inflammasome Dysregulation Updates on Diagnosis, Treatment, and the Respective Roles of IL-1 and IL-18.
Alehashemi S et al.
Frontiers in Immunology, 2020
HSC70 regulates cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4.
Raghawan AK et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
Autoinflammation with Infantile Enterocolitis Associated with Recurrent Perianal Abscesses.
Siahanidou T et al.
Journal of Clinical Immunology, 2019
Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface.
Moghaddas F et al.
The Journal of Allergy and Clinical Immunology, 2018
An Update on Autoinflammatory Diseases: Inflammasomopathies.
Harapas CR et al.
Current Rheumatology Reports, 2018
Novel aspects of the assembly and activation of inflammasomes with focus on the NLRC4 inflammasome.
Fusco WG et al.
International Immunology, 2018
ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages.
Lee BL et al.
Scientific Reports, 2018
Rapamycin as an Adjunctive Therapy for NLRC4 Associated Macrophage Activation Syndrome.
Barsalou J et al.
Frontiers in Immunology, 2018
NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease.
Nichols RD et al.
Nature Communications, 2017
Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis.
Yao X et al.
Nature Communications, 2017
NLRC4 inflammasomopathies.
Romberg N et al.
Current Opinion in Allergy and Clinical Immunology, 2017
A clinical update on inflammasomopathies.
Sönmez HE et al.
International Immunology, 2017
Genomics, Biology, and Human Illness: Advances in the Monogenic Autoinflammatory Diseases.
Oda H et al.
Rheumatic Diseases Clinics of North America, 2017
Identification of a High-Frequency Somatic NLRC4 Mutation as a Cause of Autoinflammation by Pluripotent Cell-Based Phenotype Dissection.
Kawasaki Y et al.
Arthritis & Rheumatology (hoboken, N.j.), 2017
A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death.
Raghawan AK et al.
The Journal of Biological Chemistry, 2017
Monogenic Autoinflammatory Diseases with Mendelian Inheritance: Genes, Mutations, and Genotype/Phenotype Correlations.
Martorana D et al.
Frontiers in Immunology, 2017
Newly recognized Mendelian disorders with rheumatic manifestations.
de Jesus AA et al.
Current Opinion in Rheumatology, 2015
Update on genetics and pathogenesis of autoinflammatory diseases: the last 2 years.
Aksentijevich I
Seminars in Immunopathology, 2015
Autoinflammation: NLRC4 mutation causes rare autoinflammatory disease.
Bernard NJ
Nature Reviews. Rheumatology, 2014
An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.
Canna SW et al.
Nature Genetics, 2014
Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation.
Romberg N et al.
Nature Genetics, 2014