Associated Papers
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants.
Feng S et al.
Nature Immunology, 2025
Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency.
Vande Walle L et al.
Life Science Alliance, 2024
The discovery of NLRP3 and its function in cryopyrin-associated periodic syndromes and innate immunity.
Putnam CD et al.
Immunological Reviews, 2024
HSP90β controls NLRP3 autoactivation.
Spel L et al.
Science Advances, 2024
Inflammasome Genetic Variants, Macrophage Function, and Clinical Outcomes in Cystic Fibrosis.
Graustein AD et al.
American Journal of Respiratory Cell and Molecular Biology, 2021
A novel knock-in mouse model of cryopyrin-associated periodic syndromes with development of amyloidosis: Therapeutic efficacy of proton pump inhibitors.
Bertoni A et al.
The Journal of Allergy and Clinical Immunology, 2020
Diagnosis of cryopyrin-associated periodic syndrome: challenges, recommendations and emerging concepts.
Sarrabay G et al.
Expert Review of Clinical Immunology, 2015
CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction.
Ito S et al.
Arthritis Research & Therapy, 2014
Detection of base substitution-type somatic mosaicism of the NLRP3 gene with >99.9% statistical confidence by massively parallel sequencing.
Izawa K et al.
Dna Research : an International Journal for Rapid Publication of Reports on Genes and Genomes, 2012
The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyond.
Conforti-Andreoni C et al.
Cellular & Molecular Immunology, 2011
Role of IL-1 beta in the development of human T(H)17 cells: lesson from NLPR3 mutated patients.
Lasigliè D et al.
Plos One, 2011
Diagnosis and management of autoinflammatory diseases in childhood.
Gattorno M et al.
Journal of Clinical Immunology, 2008
Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients.
Saito M et al.
Blood, 2008
A novel CIAS1mutation in a Japanese patient with chronic infantile neurological cutaneous and articular syndrome.
Takada H et al.
European Journal of Pediatrics, 2005