Varaico: Literature-Extracted Genetic Variants

Gene:NOS2
Variant:p.S608L
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NOS2

NM_000625.4:p.S608L

Associated Papers

Molecular analysis of the evolutionary history of endometrial and ovarian carcinoma in Lynch syndrome.

Kauppinen AK et al.

International Journal of Cancer, 2025

40772756 (PubMed )
Supplement: IJC-157-2294-s002.xlsx › B_Tissue_as_normal

Investigation of Genetic Polymorphisms in Inducible Nitric Oxide Synthase and Suppressor of Cytokine Signaling Genes and Pain After Root Canal Treatment.

Nascimento WM et al.

Biochemical Genetics, 2025

Association of NOS Gene Polymorphisms with Sepsis-Related Complications in Secondary Peritonitis.

Rasic M et al.

International Journal of Molecular Sciences, 2025

The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.

Wang LY et al.

Innovation (cambridge (mass.)), 2025

39991480 (PubMed )
Supplement: mmc5.xlsx › Sheet1

A polymorphism in the FAM13A gene confers protection against tuberculosis in Brazilian workers exposed to silica.

Castro MCS et al.

Jornal Brasileiro De Pneumologia : Publicacao Oficial Da Sociedade Brasileira De Pneumologia E Tisilogia, 2025

NOS2 Polymorphism in Aspect of Left and Right-Sided Colorectal Cancer.

Klusek J et al.

Journal of Clinical Medicine, 2024

Single nucleotide polymorphisms in inducible nitric oxide synthase gene are not associated with persistent apical periodontitis.

Meyfarth SRS et al.

Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc, 2023

Association of nitric oxide synthase gene polymorphism with asthma: A systematic review and meta-analysis.

Fan Z et al.

The Clinical Respiratory Journal, 2023

Female-biased association of NOS2-c.1823C>T (rs2297518) with co-susceptibility to metabolic syndrome and asthma.

Aftabi Y et al.

Canadian Journal of Physiology and Pharmacology, 2023

Genetic susceptibility in pneumoconiosis in China: a systematic review.

Chair SY et al.

International Archives of Occupational and Environmental Health, 2023

Polymorphic variations and mRNA expression of the genes encoding interleukins as well as enzymes of oxidative and nitrative stresses as a potential risk of nephrolithiasis development.

Wigner-Jeziorska P et al.

Plos One, 2023

Genomic, transcriptomic, and metabolomic profiles of hiPSC-derived dopamine neurons from clinically discordant brothers with identical PRKN deletions.

Cukier HN et al.

Npj Parkinson's Disease, 2022

35768426 (PubMed )
Supplement: 41531_2022_346_MOESM4_ESM.xlsx › Sheet1

Variation of genes encoding nitric oxide synthases and antioxidant enzymes as potential risks of multiple sclerosis development: a preliminary study.

Wigner P et al.

Scientific Reports, 2022

Inducible Nitric Oxide Synthase iNOS-954-G>C and Ex16+14-C>T Gene Polymorphisms and Susceptibility to Vitiligo in the Saudi Population.

Al-Harthi F et al.

Pharmacogenomics and Personalized Medicine, 2022

Genetic polymorphisms and their effects on the severity of silicosis in workers exposed to silica in Brazil.

Castro MCS et al.

Jornal Brasileiro De Pneumologia : Publicacao Oficial Da Sociedade Brasileira De Pneumologia E Tisilogia, 2022

Case report: Two unique nonsense mutations in HTRA1-related cerebral small vessel disease in a Chinese population and literature review.

Chen W et al.

Frontiers in Neurology, 2022

36619910 (PubMed )
Supplement: Data_Sheet_6.ZIP › case2-C › 3.________ › CA2275B________.____Exonic_Variants.xlsx › sheet1

Genome-Wide Landscape of North-Eastern European Populations: A View from Lithuania.

Urnikyte A et al.

Genes, 2021

Antioxidants-Related Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPX), Glutathione-S-Transferase (GST), and Nitric Oxide Synthase (NOS) Gene Variants Analysis in an Obese Population: A Preliminary Case-Control Study.

Gusti AMT et al.

Antioxidants (basel, Switzerland), 2021

Single-Nucleotide Polymorphisms in Oxidative Stress-Related Genes and the Risk of a Stroke in a Polish Population-A Preliminary Study.

Synowiec E et al.

Brain Sciences, 2021

Nitric oxide synthase-2 (NOS2) gene polymorphism c.1832C>T (Ser608Leu) associated with nitrosative stress in Fanconi anaemia.

George M et al.

Molecular Biology Reports, 2021

Glutathione S-Transferase (GSTT1 rs17856199) and Nitric Oxide Synthase (NOS2 rs2297518) Genotype Combination as Potential Oxidative Stress-Related Molecular Markers for Type 2 Diabetes Mellitus.

Gusti AMT et al.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2021

Genetic Analysis of Patients With Sickle Cell Anemia and Stroke Before 4 Years of Age Suggest an Important Role for Apoliprotein E.

Brewin JN et al.

Circulation. Genomic and Precision Medicine, 2020

Analysis of 47 Non-MHC Ankylosing Spondylitis Susceptibility Loci Regarding Associated Variants across Whites and Han Chinese.

Zheng X et al.

The Journal of Rheumatology, 2020

Meta-analysis and field synopsis of genetic variants associated with the risk and severity of acute pancreatitis.

van den Berg FF et al.

Bjs Open, 2020

32011822 (PubMed )
Supplement: BJS5-4-3-s001.docx

Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency.

Drutman SB et al.

The New England Journal of Medicine, 2020

Whole-Exome Sequencing Characterized the Landscape of Somatic Mutations and Pathways in Colorectal Cancer Liver Metastasis.

Feng L et al.

Journal of Oncology, 2019

31814826 (PubMed )
Supplement: 2684075.f1.zip › 2684075.f1 › Supplemental_Table_2.xlsx › Sheet1

Variation of genes involved in oxidative and nitrosative stresses in depression.

Wigner P et al.

European Psychiatry : the Journal of the Association of European Psychiatrists, 2018

The genetic association between iNOS and eNOS polymorphisms and gastric cancer risk: a meta-analysis.

Zhu Y et al.

Oncotargets and Therapy, 2018

Angiogenesis-related genes and thalidomide teratogenesis in humans: an approach on genetic variation and review of past in vitro studies.

Kowalski TW et al.

Reproductive Toxicology (elmsford, N.y.), 2017

Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis.

Chen Y et al.

Gastroenterology Research and Practice, 2017

Genetic disorders coupled to ROS deficiency.

O'Neill S et al.

Redox Biology, 2015

Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach.

Karageorgos I et al.

Human Genomics, 2015

26092435 (PubMed )
Supplement: 40246_2015_34_MOESM1_ESM.xlsx › FamilyA

Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer.

Song A et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2015

25688157 (PubMed )
Supplement: 10780432ccr141350-sup-132280_2_supp_2801337_nhwx4q.xlsx › Sheet1

Role of polymorphisms of inducible nitric oxide synthase and endothelial nitric oxide synthase in idiopathic environmental intolerances.

De Luca C et al.

Mediators of Inflammation, 2015

Endothelial Nitric Oxide Synthase G894T Polymorphism Associates with Disease Severity in Puumala Hantavirus Infection.

Koskela S et al.

Plos One, 2015

Genetic variants in inducible nitric oxide synthase gene are associated with the risk of radiation-induced lung injury in lung cancer patients receiving definitive thoracic radiation.

Zhang J et al.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology, 2014

Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease.

Dhillon SS et al.

Clinical and Translational Gastroenterology, 2014

Functional variants of eNOS and iNOS genes have no relationship to the portal hypertension in patients with liver cirrhosis.

Petrtyl J et al.

Scandinavian Journal of Gastroenterology, 2013

A non-synonymous SNP in the NOS2 associated with septic shock in patients with sepsis in Chinese populations.

Wang Z et al.

Human Genetics, 2013

Renal function and genetic polymorphisms in pediatric heart transplant recipients.

Feingold B et al.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation, 2012

The association between hepatitis C virus infection, genetic polymorphisms of oxidative stress genes and B-cell non-Hodgkin's lymphoma risk in Egypt.

Farawela H et al.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, 2012

Gene variants in the angiogenesis pathway and prostate cancer.

Amankwah EK et al.

Carcinogenesis, 2012

Acute pancreatitis is associated with Ser608Leu iNOS polymorphism.

Özhan G et al.

Folia Biologica, 2012

Ser608Leu polymorphisms in the nitric oxide synthase-2 gene may influence urinary bladder cancer pathogenesis.

Ryk C et al.

Scandinavian Journal of Urology and Nephrology, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."