Associated Papers
Functions of the native NPM1 protein and its leukemic mutant.
Falini B et al.
Leukemia, 2025
14-3-3γ prevents centrosome duplication by inhibiting NPM1 function.
Bose A et al.
Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2021
ATR signalling mediates the prosurvival function of phospho-NPM against PIDDosome mediated cell death.
Hiregange D et al.
Cellular Signalling, 2020
hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy.
Xu R et al.
Nature Communications, 2019
Nucleophosmin: from structure and function to disease development.
Box JK et al.
Bmc Molecular Biology, 2016
14-3-3γ Prevents Centrosome Amplification and Neoplastic Progression.
Mukhopadhyay A et al.
Scientific Reports, 2016
Physical and functional interaction of the TPL2 kinase with nucleophosmin.
Kanellis DC et al.
Oncogene, 2015
Phosphorylation of multifunctional nucleolar protein nucleophosmin (NPM1) by aurora kinase B is critical for mitotic progression.
Shandilya J et al.
Febs Letters, 2014
RABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts.
Zhang X et al.
Plos One, 2013
The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization.
Sekhar KR et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2011
The BRCA1 ubiquitin ligase and homologous recombination repair.
Ohta T et al.
Febs Letters, 2011
Dephosphorylation of nucleophosmin by PP1β facilitates pRB binding and consequent E2F1-dependent DNA repair.
Lin CY et al.
Molecular Biology of the Cell, 2010
Recruitment of phosphorylated NPM1 to sites of DNA damage through RNF8-dependent ubiquitin conjugates.
Koike A et al.
Cancer Research, 2010
Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication.
Krause A et al.
Plos One, 2010
Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells.
Adon AM et al.
Molecular and Cellular Biology, 2010
Nucleophosmin protein expression level, but not threonine 198 phosphorylation, is essential in growth and proliferation.
Brady SN et al.
Oncogene, 2009
p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation.
Cuomo ME et al.
Nature Cell Biology, 2008
Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing.
Tarapore P et al.
Febs Letters, 2006
Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2.
Hayami R et al.
Cancer Research, 2005
Inactivation of E2F3 results in centrosome amplification.
Saavedra HI et al.
Cancer Cell, 2003
Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.
Tokuyama Y et al.
The Journal of Biological Chemistry, 2001