Associated Papers
Modeling (not so) rare developmental disorders associated with mutations in the protein-tyrosine phosphatase SHP2.
Solman M et al.
Frontiers in Cell and Developmental Biology, 2022
Exploring the reason for increased activity of SHP2 caused by D61Y mutation through molecular dynamics.
Wang RR et al.
Computational Biology and Chemistry, 2019
Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.
Chen L et al.
Leukemia, 2015
Structural and mechanistic insights into LEOPARD syndrome-associated SHP2 mutations.
Yu ZH et al.
The Journal of Biological Chemistry, 2013
Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.
Bentires-Alj M et al.
Cancer Research, 2004
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia.
Tartaglia M et al.
Nature Genetics, 2003
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