Varaico: Literature-Extracted Genetic Variants

Gene:NR1I2
Variant:p.P27S
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NR1I2

NM_003889.4:p.P27S

Associated Papers

A comprehensive analysis and functional characterization of naturally occurring non-synonymous variants of nuclear receptor PXR.

Rana M et al.

Biochimica Et Biophysica Acta, 2016

Role of pregnane X receptor in chemotherapeutic treatment.

Zhuo W et al.

Cancer Chemotherapy and Pharmacology, 2014

The effect of fetal androgen metabolism-related gene variants on external genitalia virilization in congenital adrenal hyperplasia.

Kaupert LC et al.

Clinical Genetics, 2013

Pregnane X receptor polymorphisms associated with human diseases.

Kotta-Loizou I et al.

Expert Opinion on Therapeutic Targets, 2013

Genetic variability of PXR in Saudi Arabians.

Al-Dosari MS et al.

Biochemical Genetics, 2013

PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients.

Swart M et al.

Bmc Medical Genetics, 2012

Frequency of genetic polymorphisms of PXR gene in the Brazilian population.

Moreira RP et al.

Clinics (sao Paulo, Brazil), 2011

Nuclear receptor-mediated induction of CYP450 by antiretrovirals: functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans.

Svärd J et al.

Journal of Acquired Immune Deficiency Syndromes (1999), 2010

Identification of polymorphisms in the 3'-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolism.

Oleson L et al.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2010

PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.

Zhang B et al.

Pharmacogenomics, 2008

Sequencing and functional assessment of hPXR (NR1I2) variants in intrahepatic cholestasis of pregnancy.

Owen BM et al.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2008

Polymorphism of antimalaria drug metabolizing, nuclear receptor, and drug transport genes among malaria patients in Zanzibar, East Africa.

Ferreira PE et al.

Therapeutic Drug Monitoring, 2008

Single nucleotide polymorphisms of the pregnane x receptor gene in Han Chinese and a comparison with other ethnic populations.

Wang XD et al.

Pharmacology, 2008

Identification of NR1I2 genetic variation using resequencing.

King CR et al.

European Journal of Clinical Pharmacology, 2007

Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity.

He P et al.

Journal of Clinical Pharmacology, 2006

Screening for polymorphisms in the PXR gene in a Dutch population.

Bosch TM et al.

European Journal of Clinical Pharmacology, 2006

[Single nucleotide polymorphisms of growth hormone receptor gene in Chinese Han ethnic population].

Zhou J et al.

Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology, 2004

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants.

Zhang J et al.

Pharmacogenetics, 2001

Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotide polymorphisms.

Meyer zu Schwabedissen HE et al.

Molecular Pharmaceutics, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."