Associated Papers
Pregnane X receptor (PXR/NR1I2): linking drug metabolism, bile acid detoxification, and cholesterol homeostasis.
Ganamurali N et al.
Drug Metabolism Reviews, 2026
Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity.
Petros Z et al.
Scientific Reports, 2022
Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals.
de Almeida Velozo C et al.
The Pharmacogenomics Journal, 2022
Decoding variants in drug-metabolizing enzymes and transporters in solid tumor patients by whole-exome sequencing.
Aboul-Soud MAM et al.
Saudi Journal of Biological Sciences, 2021
Prioritization of candidate genes for a South African family with Parkinson's disease using in-silico tools.
Sebate B et al.
Plos One, 2021
Multi-Omics Characterization of the Spontaneous Mesenchymal-Epithelial Transition in the PMC42 Breast Cancer Cell Lines.
Bhatia S et al.
Journal of Clinical Medicine, 2019
Targeted next generation sequencing as a tool for precision medicine.
Gulilat M et al.
Bmc Medical Genomics, 2019
Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.
Schrader A et al.
Nature Communications, 2018
A comprehensive analysis and functional characterization of naturally occurring non-synonymous variants of nuclear receptor PXR.
Rana M et al.
Biochimica Et Biophysica Acta, 2016
Role of pregnane X receptor in chemotherapeutic treatment.
Zhuo W et al.
Cancer Chemotherapy and Pharmacology, 2014
The effect of fetal androgen metabolism-related gene variants on external genitalia virilization in congenital adrenal hyperplasia.
Kaupert LC et al.
Clinical Genetics, 2013
Pregnane X receptor polymorphisms associated with human diseases.
Kotta-Loizou I et al.
Expert Opinion on Therapeutic Targets, 2013
Genetic variability of PXR in Saudi Arabians.
Al-Dosari MS et al.
Biochemical Genetics, 2013
PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients.
Swart M et al.
Bmc Medical Genetics, 2012
Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease.
Glas J et al.
Inflammatory Bowel Diseases, 2011
Frequency of genetic polymorphisms of PXR gene in the Brazilian population.
Moreira RP et al.
Clinics (sao Paulo, Brazil), 2011
Nuclear receptor-mediated induction of CYP450 by antiretrovirals: functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans.
Svärd J et al.
Journal of Acquired Immune Deficiency Syndromes (1999), 2010
Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes.
Yang J et al.
Toxicology Letters, 2010
Identification of polymorphisms in the 3'-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolism.
Oleson L et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2010
PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.
Zhang B et al.
Pharmacogenomics, 2008
Sequencing and functional assessment of hPXR (NR1I2) variants in intrahepatic cholestasis of pregnancy.
Owen BM et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2008
Polymorphism of antimalaria drug metabolizing, nuclear receptor, and drug transport genes among malaria patients in Zanzibar, East Africa.
Ferreira PE et al.
Therapeutic Drug Monitoring, 2008
Single nucleotide polymorphisms of the pregnane x receptor gene in Han Chinese and a comparison with other ethnic populations.
Wang XD et al.
Pharmacology, 2008
Identification of NR1I2 genetic variation using resequencing.
King CR et al.
European Journal of Clinical Pharmacology, 2007
Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity.
He P et al.
Journal of Clinical Pharmacology, 2006
Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis.
Karlsen TH et al.
Gastroenterology, 2006
Screening for polymorphisms in the PXR gene in a Dutch population.
Bosch TM et al.
European Journal of Clinical Pharmacology, 2006
The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease.
Dring MM et al.
Gastroenterology, 2006
Polymorphisms of human nuclear receptors that control expression of drug-metabolizing enzymes.
Okey AB et al.
Pharmacogenetics and Genomics, 2005
[Single nucleotide polymorphisms of growth hormone receptor gene in Chinese Han ethnic population].
Zhou J et al.
Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology, 2004
The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants.
Zhang J et al.
Pharmacogenetics, 2001
Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotide polymorphisms.
Meyer zu Schwabedissen HE et al.
Molecular Pharmaceutics, 0